Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1529607..1530300 Replicon chromosome
Accession NZ_CP058302
Organism Escherichia coli strain AH65

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HUU85_RS07335 Protein ID WP_000415584.1
Coordinates 1530004..1530300 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HUU85_RS07330 Protein ID WP_000650107.1
Coordinates 1529607..1530002 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUU85_RS07320 1525471..1527729 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
HUU85_RS07325 1527867..1529474 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HUU85_RS07330 1529607..1530002 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HUU85_RS07335 1530004..1530300 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HUU85_RS07340 1530505..1530987 - 483 WP_000183505.1 transcriptional regulator -
HUU85_RS07345 1531040..1531432 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HUU85_RS07350 1531584..1532243 + 660 WP_001221493.1 two-component system response regulator QseB -
HUU85_RS07355 1532240..1533589 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HUU85_RS07360 1533635..1533968 - 334 Protein_1435 DUF2645 family protein -
HUU85_RS07365 1534287..1534868 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HUU85_RS07370 1534899..1535213 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T166448 WP_000415584.1 NZ_CP058302:c1530300-1530004 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T166448 NZ_CP074159:3978090-3978467 [Enterobacter sp. JBIWA005]
ATGCAAACCTTATCCGCCATTCCGGCTCGGAAGGCACCATCACACCCAACGCCCGTTGAAATCTGGCAGCGACTTCTTAC
GTATCTGCTGGAAAGGCATTACGGCCTTTCGCTTAACGACACACAGTTTGGCAACGACGGTGTCATTCAGCAGCATATTG
ACGCCGGGCTTTCACTGGCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTACGAATTGATCGCCCCGGTTTC
TCCATTCAGCATCAGTCTCCGTTCATCAGCGCTATTGATATACTCCGGGCCAGAAAGGCCATCGGCCTGATGCAACGTAC
CGGTTATAAAGCGGTGACTTGCGCCATCAGTGGACGCTCTTCCGGAGGGCTGAAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT166448 WP_000650107.1 NZ_CP058302:c1530002-1529607 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT166448 NZ_CP074159:3977668-3978033 [Enterobacter sp. JBIWA005]
ATGCCGAACACAACACCTGTAGCAAACCATGATATTTCTGAGCCCTGGTGGGGACTTAAACCCACCGTCACGCCATGCTT
TGGCGCACGACTGGTACAGGAAGGCAACCACCTGCATTATCTGGCTGACCGCAGCACTATCGAAGGAACATTCAGCGACG
CGGATTTACGTCATCTCGACCAGGCCTTTCCGGTACTAATGAAGCAGCTTGAGTTAATGCTGGTTTCCGGTGAACTCAAT
CCCCGCAATCAGCATTGCGTCACGTTGTATGCAAAAGGTCTGACCCTCGACGCAGATACACTGGGCAGTTGTGGTTACCT
TTATATCGCGATTTATCCGACGTCAGGCAACAGCATCCCCCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References