Detailed information of TA system TA166434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 557091..557679
• Replicon: chromosome
• Accession: NZ_CP058287
• Organism: Helicobacter pylori strain AL04

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: J0ILK7
• Locus tag: HWU09_RS02670
• Protein ID: WP_000921935.1
• Coordinates: 557091..557372 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HWU09_RS02675
• Protein ID: WP_237003755.1
• Coordinates: 557365..557679 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWU09_RS02635 (552292)	552292..552555	+	264	WP_237003751.1	hypothetical protein	-
HWU09_RS02640 (552552)	552552..552851	+	300	WP_078286912.1	hypothetical protein	-
HWU09_RS02645 (552851)	552851..553790	+	940	Protein_521	ATPase, T2SS/T4P/T4SS family	-
HWU09_RS02650 (553787)	553787..554242	+	456	WP_237003752.1	mobilization protein	-
HWU09_RS02655 (554239)	554239..554529	+	291	WP_000159828.1	hypothetical protein	-
HWU09_RS02660 (554530)	554530..555087	+	558	WP_237003753.1	hypothetical protein	-
HWU09_RS02665 (555088)	555088..556815	+	1728	WP_237003754.1	type IV secretory system conjugative DNA transfer family protein	-
HWU09_RS02670 (557091)	557091..557372	-	282	WP_000921935.1	YafQ family addiction module toxin	Toxin
HWU09_RS02675 (557365)	557365..557679	-	315	WP_237003755.1	hypothetical protein	Antitoxin
HWU09_RS02680 (557974)	557974..559884	+	1911	WP_237003756.1	relaxase/mobilization nuclease domain-containing protein	-
HWU09_RS02685 (559909)	559909..561093	-	1185	WP_237003757.1	hypothetical protein	-
HWU09_RS02690 (561125)	561125..561409	-	285	WP_000394639.1	hypothetical protein	-
HWU09_RS02695 (561491)	561491..562147	-	657	WP_000587395.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10861.77 Da
• Isoelectric Point: 9.5726

>T166434 WP_000921935.1 NZ_CP058287:c557372-557091 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T166434 NZ_CP074154:1661136-1661510 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGAACGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATTGCGCGATGGGAAGAACCCTTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12167.69 Da
• Isoelectric Point: 6.4648

>AT166434 WP_237003755.1 NZ_CP058287:c557679-557365 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPK
CDVSFGDFNDFLQIARQERERRNA

Nucleotide

• Length: 315 bp

>AT166434 NZ_CP074154:1661494-1661796 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTGTAG

Structures

Toxin

• AlphaFold DB: A0A0L0PNN7