Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1593422..1594010 Replicon chromosome
Accession NZ_CP058281
Organism Helicobacter pylori strain Hk711

Toxin (Protein)


Gene name TfiT Uniprot ID J0ILK7
Locus tag HWU15_RS07555 Protein ID WP_000921935.1
Coordinates 1593729..1594010 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID G2MA82
Locus tag HWU15_RS07550 Protein ID WP_000065286.1
Coordinates 1593422..1593736 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWU15_RS07530 1588954..1589610 + 657 WP_000587395.1 ParA family protein -
HWU15_RS07535 1589692..1589976 + 285 WP_000394639.1 hypothetical protein -
HWU15_RS07540 1590008..1591192 + 1185 WP_237015441.1 hypothetical protein -
HWU15_RS07545 1591216..1593126 - 1911 WP_237015442.1 relaxase/mobilization nuclease domain-containing protein -
HWU15_RS07550 1593422..1593736 + 315 WP_000065286.1 hypothetical protein Antitoxin
HWU15_RS07555 1593729..1594010 + 282 WP_000921935.1 YafQ family addiction module toxin Toxin
HWU15_RS07560 1594284..1596011 - 1728 WP_237015443.1 type IV secretory system conjugative DNA transfer family protein -
HWU15_RS07565 1596012..1596569 - 558 WP_237015444.1 hypothetical protein -
HWU15_RS07570 1596570..1596860 - 291 WP_000159826.1 hypothetical protein -
HWU15_RS07575 1596857..1597312 - 456 WP_237015445.1 mobilization protein -
HWU15_RS07580 1597309..1598250 - 942 WP_000625132.1 ATPase, T2SS/T4P/T4SS family -
HWU15_RS07585 1598250..1598549 - 300 WP_180532112.1 hypothetical protein -
HWU15_RS07590 1598546..1598809 - 264 WP_231247366.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1560752..1646731 85979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10861.77 Da        Isoelectric Point: 9.5726

>T166432 WP_000921935.1 NZ_CP058281:1593729-1594010 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T166432 NZ_CP074154:807270-807680 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTAAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12140.62 Da        Isoelectric Point: 5.2248

>AT166432 WP_000065286.1 NZ_CP058281:1593422-1593736 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT166432 NZ_CP074154:807023-807289 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0PNN7

Antitoxin

Source ID Structure
AlphaFold DB G2MA82

References