Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3090794..3091473 Replicon chromosome
Accession NZ_CP058277
Organism Mycobacterium marinum strain MMA1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HXW97_RS13180 Protein ID WP_202098300.1
Coordinates 3091120..3091473 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HXW97_RS13175 Protein ID WP_202098299.1
Coordinates 3090794..3091123 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXW97_RS13145 3086611..3087624 - 1014 WP_202098296.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
HXW97_RS13155 3088287..3088526 - 240 WP_033718505.1 hypothetical protein -
HXW97_RS13160 3088623..3089477 - 855 WP_065517432.1 hypothetical protein -
HXW97_RS13165 3089542..3089994 - 453 WP_202098297.1 GNAT family N-acetyltransferase -
HXW97_RS13170 3089991..3090662 - 672 WP_202098298.1 hypothetical protein -
HXW97_RS13175 3090794..3091123 - 330 WP_202098299.1 helix-turn-helix transcriptional regulator Antitoxin
HXW97_RS13180 3091120..3091473 - 354 WP_202098300.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXW97_RS13185 3091520..3092700 - 1181 Protein_2609 site-specific integrase -
HXW97_RS13190 3092704..3092934 - 231 Protein_2610 Arm DNA-binding domain-containing protein -
HXW97_RS13195 3092844..3093032 - 189 WP_202098392.1 helix-turn-helix domain-containing protein -
HXW97_RS13200 3093004..3093855 - 852 WP_202098301.1 helix-turn-helix domain-containing protein -
HXW97_RS13205 3094200..3094571 - 372 WP_202098302.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-94)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13249.02 Da        Isoelectric Point: 4.4709

>T166428 WP_202098300.1 NZ_CP058277:c3091473-3091120 [Mycobacterium marinum]
MSTSWYVILLEEVETWYFSLDDDAMAAVTGAVDLLELEGPTLGRPTVDKVRGSKFHSLKELRPAGTSIRILFIFDPRRQA
ILLLGGDKAGNWTSWYDKNIPIAERRYEDWLATEGGE

Download         Length: 354 bp

>T166428 NZ_CP074149:c2901488-2901385 [Enterobacter sp. JBIWA008]
GGCAGGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11921.45 Da        Isoelectric Point: 8.7636

>AT166428 WP_202098299.1 NZ_CP058277:c3091123-3090794 [Mycobacterium marinum]
MSMARNWRDIRADAIAQGRLDPARADAARNEMHDAVQAHRLAEIRKAQGHRRQADVAVLMGVSQARVSKLESGDLSHTQL
GTLQSYVAALGGSLRVVAEFDEKTVELTT

Download         Length: 330 bp

>AT166428 NZ_CP074149:2901380-2901523 [Enterobacter sp. JBIWA008]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCCTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References