Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2998401..2999049 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A7U8TVG5
Locus tag HWS75_RS14130 Protein ID WP_003909715.1
Coordinates 2998401..2998724 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag HWS75_RS14135 Protein ID WP_003899415.1
Coordinates 2998804..2999049 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS14100 2993724..2994722 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
HWS75_RS14105 2994736..2995200 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
HWS75_RS14110 2995188..2995439 + 252 WP_003908028.1 hypothetical protein -
HWS75_RS14115 2995610..2997049 - 1440 WP_003901443.1 phage major capsid protein -
HWS75_RS14120 2997057..2997590 - 534 WP_003899412.1 HK97 family phage prohead protease -
HWS75_RS14125 2997743..2998234 - 492 WP_003900541.1 phage terminase small subunit P27 family -
HWS75_RS14130 2998401..2998724 - 324 WP_003909715.1 type II toxin-antitoxin system toxin Toxin
HWS75_RS14135 2998804..2999049 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
HWS75_RS14140 2999046..3000473 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
HWS75_RS14145 3000475..3000867 - 393 WP_003899417.1 DUF2742 domain-containing protein -
HWS75_RS14150 3000864..3001124 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
HWS75_RS14155 3001141..3001503 - 363 WP_003900543.1 hypothetical protein -
HWS75_RS14160 3001506..3002633 - 1128 WP_003899420.1 site-specific integrase -
HWS75_RS14165 3002778..3003005 - 228 WP_003909716.1 hypothetical protein -
HWS75_RS14170 3003002..3003391 - 390 WP_003899422.1 hypothetical protein -
HWS75_RS14175 3003297..3003569 + 273 WP_003900544.1 hypothetical protein -
HWS75_RS14180 3003668..3003901 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2993724..3002633 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.81 Da        Isoelectric Point: 8.6568

>T166366 WP_003909715.1 NZ_CP058236:c2998724-2998401 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T166366 NZ_CP074140:3695185-3695373 [Serratia sp. JSRIV004]
GTGAAAAGTTCAGAACTGATTAAACGACTCGAAAGCCATGGTTGGGTTCTACAACGGATCAAAGGCAGCCACCATCAATT
CAAACACCCCAACTCATCGTTGGTGATCACCGTGCCTCATCCCAATAAGGATGTGAAATTGGGAACGCTGCGGCAAATCA
TGAAGGATGCAGGGTTGCTTAATTCCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT166366 WP_003899415.1 NZ_CP058236:c2999049-2998804 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT166366 NZ_CP074140:3695401-3695814 [Serratia sp. JSRIV004]
ATGTTTTATCCCGCTTATATACATGCCGAGCCAGATGGCAGCGCCAGCGGCTTTTTTCCCGATGTGCCCGGCTGCTACTT
TGCCGGAGTCAGTCTCGATCAAACCTTCCAGGACGCCAAAAGCGCTCTGGATGCCCACTTTGAATTATTGAGTGAAAACA
ATCAGGTCATTCCACGCCCACAGGCAGTGTCCTTCCATCTGGCTCAGGACAACGACGCTCTCAACGGCGGCCAGTGGTTG
CTGGTGGATATTAATATGGACAAGTTTGATGGCCGGGCAGAACGCATCAATATCACGTTGCCCCATAGGCTGCTCAACCG
TATTGATGCGCTGGTGCAGCAGCATCCGGGCTATGGCAGCCGCAGCGCATTTCTCGCCGCCGCAGCGCGTAATGAGTTGT
TAAAGGCAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8TVG5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References