Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2226691..2227559 | Replicon | chromosome |
| Accession | NZ_CP058236 | ||
| Organism | Mycobacterium tuberculosis strain 060827 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | HWS75_RS10390 | Protein ID | WP_010886136.1 |
| Coordinates | 2226691..2227068 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | HWS75_RS10395 | Protein ID | WP_003409886.1 |
| Coordinates | 2227110..2227559 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWS75_RS10340 | 2222480..2222932 | - | 453 | WP_003899095.1 | lipoprotein | - |
| HWS75_RS10345 | 2222996..2223397 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| HWS75_RS10350 | 2223390..2223572 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| HWS75_RS10355 | 2223686..2224036 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| HWS75_RS10360 | 2224047..2224949 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| HWS75_RS10365 | 2224970..2225161 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| HWS75_RS10370 | 2225162..2225458 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| HWS75_RS10375 | 2225698..2225913 | + | 216 | WP_003409878.1 | antitoxin | - |
| HWS75_RS10380 | 2225910..2226221 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| HWS75_RS10385 | 2226195..2226716 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| HWS75_RS10390 | 2226691..2227068 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| HWS75_RS10395 | 2227110..2227559 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| HWS75_RS10400 | 2227556..2228101 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| HWS75_RS10405 | 2227990..2228604 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| HWS75_RS10410 | 2228653..2228949 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HWS75_RS10415 | 2228946..2229197 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| HWS75_RS10420 | 2229184..2229678 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| HWS75_RS10425 | 2229838..2230245 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| HWS75_RS10430 | 2230249..2230521 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HWS75_RS10435 | 2230554..2231774 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T166350 WP_010886136.1 NZ_CP058236:2226691-2227068 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T166350 NZ_CP074137:4852436-4852771 [Serratia sp. JSRIV006]
ATGACGATGATCAACACCGCCACACCGATTGCCGCCAATGCCCGTCAGGCCTTGGCCGAATACCAGCAGTTGCTCACCTG
GCTGTTGGGTCACTGCTATGGCTTGGAACTAAACGATACGCCGTATCACGACGACCAGGCGATTATCCAGCAGATTGAAC
ATGGCATTACCGTAAGGGAAACCGTCAATGAACTGGTGGAGAAATTCGATCTGGTCCGAATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCGACGCTGAACGGCGGGGATATGCTCCGTGCCCGCAGTGCGCTGGGATTACGCAGTCCCATCAT
TCGACGTCTCACCTGA
ATGACGATGATCAACACCGCCACACCGATTGCCGCCAATGCCCGTCAGGCCTTGGCCGAATACCAGCAGTTGCTCACCTG
GCTGTTGGGTCACTGCTATGGCTTGGAACTAAACGATACGCCGTATCACGACGACCAGGCGATTATCCAGCAGATTGAAC
ATGGCATTACCGTAAGGGAAACCGTCAATGAACTGGTGGAGAAATTCGATCTGGTCCGAATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCGACGCTGAACGGCGGGGATATGCTCCGTGCCCGCAGTGCGCTGGGATTACGCAGTCCCATCAT
TCGACGTCTCACCTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT166350 WP_003409886.1 NZ_CP058236:2227110-2227559 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT166350 NZ_CP074137:4852851-4853237 [Serratia sp. JSRIV006]
ATGAAAGAACCCATTACCGATAACCATACCGCCCCCCTCACCGACGACAACAGCACGCCGTCAACGACCTGGGGCCTGCA
ATCTGCTATTACGCCACGCCTGGGTGCCCGACTGGTGCAACAGGGTGATCGTCTGCATTTTCTGGCTGATCGTGCTGGTC
TGCTTGGTACATTTTCACCCGACGACCTCAAGGCGCTGGATGAGGCGTTTCCGGTGTTGATTGAGCAACTGGAAGCCTGT
TTGCGCTCTGGTGAGCTCGATCAACGTCGTCAGCAGAGTGTCACGCTCCAACACGCCGGTTTTAGCTGTGAAGCAGACAC
CTTGGGCAGCTTTGGCCATGTCTACATAGCAATTTATCACGCGACTCAGTCCCCCGGTAACGAATGA
ATGAAAGAACCCATTACCGATAACCATACCGCCCCCCTCACCGACGACAACAGCACGCCGTCAACGACCTGGGGCCTGCA
ATCTGCTATTACGCCACGCCTGGGTGCCCGACTGGTGCAACAGGGTGATCGTCTGCATTTTCTGGCTGATCGTGCTGGTC
TGCTTGGTACATTTTCACCCGACGACCTCAAGGCGCTGGATGAGGCGTTTCCGGTGTTGATTGAGCAACTGGAAGCCTGT
TTGCGCTCTGGTGAGCTCGATCAACGTCGTCAGCAGAGTGTCACGCTCCAACACGCCGGTTTTAGCTGTGAAGCAGACAC
CTTGGGCAGCTTTGGCCATGTCTACATAGCAATTTATCACGCGACTCAGTCCCCCGGTAACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|