Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2226691..2227559 | Replicon | chromosome |
| Accession | NZ_CP058236 | ||
| Organism | Mycobacterium tuberculosis strain 060827 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | HWS75_RS10390 | Protein ID | WP_010886136.1 |
| Coordinates | 2226691..2227068 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | HWS75_RS10395 | Protein ID | WP_003409886.1 |
| Coordinates | 2227110..2227559 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T166350 WP_010886136.1 NZ_CP058236:2226691-2227068 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T166350 NZ_CP074137:4852436-4852771 [Serratia sp. JSRIV006]
ATGACGATGATCAACACCGCCACACCGATTGCCGCCAATGCCCGTCAGGCCTTGGCCGAATACCAGCAGTTGCTCACCTG
GCTGTTGGGTCACTGCTATGGCTTGGAACTAAACGATACGCCGTATCACGACGACCAGGCGATTATCCAGCAGATTGAAC
ATGGCATTACCGTAAGGGAAACCGTCAATGAACTGGTGGAGAAATTCGATCTGGTCCGAATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCGACGCTGAACGGCGGGGATATGCTCCGTGCCCGCAGTGCGCTGGGATTACGCAGTCCCATCAT
TCGACGTCTCACCTGA
ATGACGATGATCAACACCGCCACACCGATTGCCGCCAATGCCCGTCAGGCCTTGGCCGAATACCAGCAGTTGCTCACCTG
GCTGTTGGGTCACTGCTATGGCTTGGAACTAAACGATACGCCGTATCACGACGACCAGGCGATTATCCAGCAGATTGAAC
ATGGCATTACCGTAAGGGAAACCGTCAATGAACTGGTGGAGAAATTCGATCTGGTCCGAATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCGACGCTGAACGGCGGGGATATGCTCCGTGCCCGCAGTGCGCTGGGATTACGCAGTCCCATCAT
TCGACGTCTCACCTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT166350 WP_003409886.1 NZ_CP058236:2227110-2227559 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT166350 NZ_CP074137:4852851-4853237 [Serratia sp. JSRIV006]
ATGAAAGAACCCATTACCGATAACCATACCGCCCCCCTCACCGACGACAACAGCACGCCGTCAACGACCTGGGGCCTGCA
ATCTGCTATTACGCCACGCCTGGGTGCCCGACTGGTGCAACAGGGTGATCGTCTGCATTTTCTGGCTGATCGTGCTGGTC
TGCTTGGTACATTTTCACCCGACGACCTCAAGGCGCTGGATGAGGCGTTTCCGGTGTTGATTGAGCAACTGGAAGCCTGT
TTGCGCTCTGGTGAGCTCGATCAACGTCGTCAGCAGAGTGTCACGCTCCAACACGCCGGTTTTAGCTGTGAAGCAGACAC
CTTGGGCAGCTTTGGCCATGTCTACATAGCAATTTATCACGCGACTCAGTCCCCCGGTAACGAATGA
ATGAAAGAACCCATTACCGATAACCATACCGCCCCCCTCACCGACGACAACAGCACGCCGTCAACGACCTGGGGCCTGCA
ATCTGCTATTACGCCACGCCTGGGTGCCCGACTGGTGCAACAGGGTGATCGTCTGCATTTTCTGGCTGATCGTGCTGGTC
TGCTTGGTACATTTTCACCCGACGACCTCAAGGCGCTGGATGAGGCGTTTCCGGTGTTGATTGAGCAACTGGAAGCCTGT
TTGCGCTCTGGTGAGCTCGATCAACGTCGTCAGCAGAGTGTCACGCTCCAACACGCCGGTTTTAGCTGTGAAGCAGACAC
CTTGGGCAGCTTTGGCCATGTCTACATAGCAATTTATCACGCGACTCAGTCCCCCGGTAACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|