Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1815656..1816455 Replicon chromosome
Accession NZ_CP058223
Organism Escherichia coli strain 550

Toxin (Protein)


Gene name yhaV Uniprot ID B7NDB6
Locus tag HWQ66_RS08530 Protein ID WP_000347269.1
Coordinates 1815656..1816120 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID V0YUB5
Locus tag HWQ66_RS08535 Protein ID WP_001309780.1
Coordinates 1816120..1816455 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ66_RS08500 1810657..1811091 - 435 WP_000948818.1 PTS sugar transporter subunit IIA -
HWQ66_RS08505 1811109..1811987 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HWQ66_RS08510 1811977..1812756 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HWQ66_RS08515 1812767..1813240 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HWQ66_RS08520 1813263..1814543 - 1281 WP_000681943.1 tagatose-bisphosphate aldolase subunit KbaZ -
HWQ66_RS08525 1814792..1815601 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
HWQ66_RS08530 1815656..1816120 - 465 WP_000347269.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HWQ66_RS08535 1816120..1816455 - 336 WP_001309780.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HWQ66_RS08540 1816604..1818175 - 1572 WP_001273738.1 galactarate dehydratase -
HWQ66_RS08545 1818550..1819884 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
HWQ66_RS08550 1819900..1820670 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1815656..1826824 11168


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T166262 WP_000347269.1 NZ_CP058223:c1816120-1815656 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH

Download         Length: 465 bp

>T166262 NZ_CP074098:c1968380-1968277 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12345.94 Da        Isoelectric Point: 4.8616

>AT166262 WP_001309780.1 NZ_CP058223:c1816455-1816120 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT166262 NZ_CP074098:1968275-1968418 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IY86

Antitoxin

Source ID Structure
AlphaFold DB V0YUB5

References