Detailed information of TA system TA166257

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 363311..363569
• Replicon: chromosome
• Accession: NZ_CP058223
• Organism: Escherichia coli strain 550

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HWQ66_RS01630
• Protein ID: WP_000809168.1
• Coordinates: 363417..363569 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	363311..363368 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWQ66_RS01615	359703..360662	+	960	WP_000871674.1	hypothetical protein	-
HWQ66_RS01620	360700..361599	-	900	WP_001300855.1	transcriptional activator NhaR	-
HWQ66_RS01625	361665..362831	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	363311..363368	-	58	-	-	Antitoxin
HWQ66_RS01630	363417..363569	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HWQ66_RS01635	363673..364803	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HWQ66_RS01640	364892..366808	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HWQ66_RS01645	367184..367588	+	405	WP_000843584.1	DUF2541 family protein	-
HWQ66_RS01650	367614..368327	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T166257 WP_000809168.1 NZ_CP058223:363417-363569 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T166257 NZ_CP074097:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT166257 NZ_CP058223:c363368-363311 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin