Detailed information of TA system TA166248

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4374625..4374883
• Replicon: chromosome
• Accession: NZ_CP058222
• Organism: Escherichia coli strain CFT073

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HW370_RS21270
• Protein ID: WP_000809168.1
• Coordinates: 4374731..4374883 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4374625..4374682 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW370_RS21255	4370454..4371713	-	1260	WP_000494928.1	hypothetical protein	-
HW370_RS21260	4371842..4373335	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HW370_RS21265	4373355..4374116	-	762	WP_001274832.1	outer membrane protein OmpK	-
-	4374625..4374682	-	58	-	-	Antitoxin
HW370_RS21270	4374731..4374883	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HW370_RS21275	4374988..4376118	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HW370_RS21280	4376207..4378123	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HW370_RS21285	4378495..4378899	+	405	WP_000843687.1	DUF2541 family protein	-
HW370_RS21290	4378925..4379638	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T166248 WP_000809168.1 NZ_CP058222:4374731-4374883 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T166248 NZ_CP074096:c3206776-3206363 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT166248 NZ_CP058222:c4374682-4374625 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin