Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 2199640..2199898 Replicon chromosome
Accession NZ_CP058209
Organism Escherichia marmotae strain RHB24-C12

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag HVY12_RS10740 Protein ID WP_000935262.1
Coordinates 2199689..2199898 (+) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2199640..2199697 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY12_RS10715 2195395..2196336 - 942 WP_000767344.1 bifunctional riboflavin kinase/FAD synthetase -
HVY12_RS10720 2196344..2196562 - 219 Protein_2100 DUF2575 domain-containing protein -
HVY12_RS10725 2196665..2196928 + 264 WP_001274018.1 30S ribosomal protein S20 -
HVY12_RS10730 2197031..2197936 - 906 WP_000062876.1 transcriptional activator NhaR -
HVY12_RS10735 2197996..2199162 - 1167 WP_000681378.1 Na+/H+ antiporter NhaA -
- 2199640..2199697 - 58 - - Antitoxin
HVY12_RS10740 2199689..2199898 + 210 WP_000935262.1 type I toxin-antitoxin system Hok family toxin Toxin
HVY12_RS10745 2200003..2201133 - 1131 WP_001118463.1 molecular chaperone DnaJ -
HVY12_RS10750 2201222..2203138 - 1917 WP_000516135.1 molecular chaperone DnaK -
HVY12_RS10755 2203515..2203767 + 253 Protein_2107 DUF2541 family protein -
HVY12_RS10760 2204007..2204573 + 567 WP_000528538.1 acetate uptake transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-66)


Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7742.28 Da        Isoelectric Point: 9.3680

>T166139 WP_000935262.1 NZ_CP058209:2199689-2199898 [Escherichia marmotae]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T166139 NZ_CP074047:179260-179367 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT166139 NZ_CP058209:c2199697-2199640 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References