Detailed information of TA system TA166135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1063802..1064027
• Replicon: chromosome
• Accession: NZ_CP058209
• Organism: Escherichia marmotae strain RHB24-C12

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: HVY12_RS05480
• Protein ID: WP_000018423.1
• Coordinates: 1063802..1064014 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1063969..1064027 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY12_RS05445	1059464..1060510	-	1047	WP_181237993.1	site-specific DNA-methyltransferase	-
HVY12_RS05450	1060661..1060858	-	198	WP_000917767.1	hypothetical protein	-
HVY12_RS05455	1061079..1061579	-	501	WP_063084977.1	hypothetical protein	-
HVY12_RS05460	1061561..1061941	-	381	WP_000090267.1	late gene antiterminator protein	-
HVY12_RS05465	1061931..1062302	-	372	WP_112041967.1	RusA family crossover junction endodeoxyribonuclease	-
HVY12_RS05470	1062315..1063361	-	1047	WP_181237994.1	DUF968 domain-containing protein	-
HVY12_RS05475	1063363..1063635	-	273	WP_012565094.1	hypothetical protein	-
HVY12_RS05480	1063802..1064014	-	213	WP_000018423.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	1063969..1064027	+	59	-	-	Antitoxin
HVY12_RS05485	1064248..1064508	-	261	WP_063123881.1	hypothetical protein	-
HVY12_RS05490	1064548..1064820	-	273	Protein_1078	hypothetical protein	-
HVY12_RS05495	1064824..1065228	-	405	WP_181237995.1	hypothetical protein	-
HVY12_RS05500	1065367..1065726	-	360	WP_063123852.1	hypothetical protein	-
HVY12_RS05505	1065723..1065899	-	177	WP_000753067.1	hypothetical protein	-
HVY12_RS05510	1065892..1066074	-	183	WP_024238437.1	hypothetical protein	-
HVY12_RS05515	1066170..1066694	-	525	WP_097333611.1	ead/Ea22-like family protein	-
HVY12_RS05520	1066681..1066947	-	267	WP_000004320.1	hypothetical protein	-
HVY12_RS05525	1066944..1067336	-	393	WP_181237996.1	DUF977 family protein	-
HVY12_RS05530	1067351..1068097	-	747	WP_181237997.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1032972..1080732	47760

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7911.50 Da
• Isoelectric Point: 9.7078

>T166135 WP_000018423.1 NZ_CP058209:c1064014-1063802 [Escherichia marmotae]
MSHKCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T166135 NZ_CP074042:c4066528-4066178 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT166135 NZ_CP058209:1063969-1064027 [Escherichia marmotae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Antitoxin