Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 529784..530346 Replicon chromosome
Accession NZ_CP058209
Organism Escherichia marmotae strain RHB24-C12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY12_RS02680 Protein ID WP_181237923.1
Coordinates 530068..530346 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVY12_RS02675 Protein ID WP_000781370.1
Coordinates 529784..530068 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY12_RS02660 524967..528014 + 3048 WP_077633351.1 formate dehydrogenase-N subunit alpha -
HVY12_RS02665 528027..528911 + 885 WP_001240589.1 formate dehydrogenase N subunit beta -
HVY12_RS02670 528904..529557 + 654 WP_000045637.1 formate dehydrogenase-N subunit gamma -
HVY12_RS02675 529784..530068 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVY12_RS02680 530068..530346 - 279 WP_181237923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY12_RS02685 530532..531542 - 1011 WP_000642389.1 alcohol dehydrogenase AdhP -
HVY12_RS02690 531676..533373 - 1698 WP_000433452.1 malate dehydrogenase -
HVY12_RS02695 533536..533685 - 150 WP_181237924.1 stationary-phase-induced ribosome-associated protein -
HVY12_RS02700 533776..533991 - 216 WP_000495761.1 biofilm-dependent modulation protein -
HVY12_RS02705 534314..534745 + 432 WP_000152293.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10540.12 Da        Isoelectric Point: 6.4709

>T166125 WP_181237923.1 NZ_CP058209:c530346-530068 [Escherichia marmotae]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDCDEIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T166125 NZ_CP074042:1837598-1837849 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT166125 WP_000781370.1 NZ_CP058209:c530068-529784 [Escherichia marmotae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT166125 NZ_CP074042:1837846-1838100 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References