Detailed information of TA system TA166120

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 316055..316278
• Replicon: chromosome
• Accession: NZ_CP058209
• Organism: Escherichia marmotae strain RHB24-C12

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A7H9K3A2
• Locus tag: HVY12_RS01710
• Protein ID: WP_032141347.1
• Coordinates: 316055..316162 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	316212..316278 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY12_RS01685	311868..312950	+	1083	WP_000804714.1	peptide chain release factor 1	-
HVY12_RS01690	312950..313783	+	834	WP_181237894.1	peptide chain release factor N(5)-glutamine methyltransferase	-
HVY12_RS01695	313780..314172	+	393	WP_000200357.1	invasion regulator SirB2	-
HVY12_RS01700	314176..314985	+	810	WP_001257034.1	invasion regulator SirB1	-
HVY12_RS01705	315021..315875	+	855	WP_000811071.1	3-deoxy-8-phosphooctulonate synthase	-
HVY12_RS01710	316055..316162	-	108	WP_032141347.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	316212..316278	+	67	-	-	Antitoxin
HVY12_RS01715	316571..317671	-	1101	WP_001516524.1	sodium-potassium/proton antiporter ChaA	-
HVY12_RS01720	317940..318170	+	231	WP_001146437.1	putative cation transport regulator ChaB	-
HVY12_RS01725	318328..319023	+	696	WP_016248767.1	glutathione-specific gamma-glutamylcyclotransferase	-
HVY12_RS01730	319067..319420	-	354	WP_001169672.1	DsrE/F sulfur relay family protein YchN	-
HVY12_RS01735	319604..320998	+	1395	WP_016248766.1	YchO/YchP family invasin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3953.71 Da
• Isoelectric Point: 11.4779

>T166120 WP_032141347.1 NZ_CP058209:c316162-316055 [Escherichia marmotae]
MTLAQFAITFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T166120 NZ_CP074042:329306-329833 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT166120 NZ_CP058209:316212-316278 [Escherichia marmotae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7H9K3A2

Antitoxin