Detailed information of TA system TA166116

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-symR/Ldr(toxin)
• Location: 2540723..2540946
• Replicon: chromosome
• Accession: NZ_CP058207
• Organism: Escherichia marmotae strain RHB42-C09

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A7H9K3A2
• Locus tag: HV018_RS11925
• Protein ID: WP_032141347.1
• Coordinates: 2540839..2540946 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	2540723..2540789 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV018_RS11900	2536003..2537397	-	1395	WP_016248766.1	YchO/YchP family invasin	-
HV018_RS11905	2537581..2537934	+	354	WP_001169672.1	DsrE/F sulfur relay family protein YchN	-
HV018_RS11910	2537978..2538673	-	696	WP_001516523.1	glutathione-specific gamma-glutamylcyclotransferase	-
HV018_RS11915	2538831..2539061	-	231	WP_001146437.1	putative cation transport regulator ChaB	-
HV018_RS11920	2539330..2540430	+	1101	WP_001516524.1	sodium-potassium/proton antiporter ChaA	-
-	2540723..2540789	-	67	-	-	Antitoxin
HV018_RS11925	2540839..2540946	+	108	WP_032141347.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
HV018_RS11930	2541126..2541980	-	855	WP_000811071.1	3-deoxy-8-phosphooctulonate synthase	-
HV018_RS11935	2542016..2542825	-	810	WP_001257034.1	invasion regulator SirB1	-
HV018_RS11940	2542829..2543221	-	393	WP_000200357.1	invasion regulator SirB2	-
HV018_RS11945	2543218..2544051	-	834	WP_001516525.1	peptide chain release factor N(5)-glutamine methyltransferase	-
HV018_RS11950	2544051..2545133	-	1083	WP_001516526.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3953.71 Da
• Isoelectric Point: 11.4779

>T166116 WP_032141347.1 NZ_CP058207:2540839-2540946 [Escherichia marmotae]
MTLAQFAITFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T166116 NZ_CP074035:c2183-1803 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGCGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGTAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT166116 NZ_CP058207:c2540789-2540723 [Escherichia marmotae]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7H9K3A2

Antitoxin