Detailed information of TA system TA166102

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 689124..689382
• Replicon: chromosome
• Accession: NZ_CP058207
• Organism: Escherichia marmotae strain RHB42-C09

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HV018_RS03135
• Protein ID: WP_000935262.1
• Coordinates: 689124..689333 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	689325..689382 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV018_RS03115	684449..685015	-	567	WP_000528538.1	acetate uptake transporter	-
HV018_RS03120	685255..685507	-	253	Protein_601	DUF2541 family protein	-
HV018_RS03125	685884..687800	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HV018_RS03130	687889..689019	+	1131	WP_001118463.1	molecular chaperone DnaJ	-
HV018_RS03135	689124..689333	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	689325..689382	+	58	-	-	Antitoxin
HV018_RS03140	689860..691026	+	1167	WP_000681378.1	Na+/H+ antiporter NhaA	-
HV018_RS03145	691086..691991	+	906	WP_000062876.1	transcriptional activator NhaR	-
HV018_RS03150	692094..692357	-	264	WP_001274018.1	30S ribosomal protein S20	-
HV018_RS03155	692460..692678	+	219	Protein_608	DUF2575 domain-containing protein	-
HV018_RS03160	692686..693627	+	942	WP_001517719.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T166102 WP_000935262.1 NZ_CP058207:c689333-689124 [Escherichia marmotae]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T166102 NZ_CP074033:c2621608-2621258 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT166102 NZ_CP058207:689325-689382 [Escherichia marmotae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin