Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2083121..2083781 Replicon chromosome
Accession NZ_CP058180
Organism Klebsiella grimontii strain RHBSTW-00039

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV042_RS10015 Protein ID WP_049085818.1
Coordinates 2083121..2083474 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag HV042_RS10020 Protein ID WP_004132739.1
Coordinates 2083479..2083781 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV042_RS09990 2078505..2079272 - 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -
HV042_RS09995 2079262..2079870 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
HV042_RS10000 2079885..2080511 - 627 WP_004132731.1 hypothetical protein -
HV042_RS10005 2080651..2081319 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
HV042_RS10010 2081319..2082737 + 1419 WP_049085817.1 heavy metal sensor histidine kinase -
HV042_RS10015 2083121..2083474 + 354 WP_049085818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV042_RS10020 2083479..2083781 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
HV042_RS10025 2083872..2084042 + 171 WP_177929058.1 helix-turn-helix domain-containing protein -
HV042_RS10030 2084165..2084368 + 204 Protein_1968 hypothetical protein -
HV042_RS10035 2084369..2084701 + 333 WP_024359977.1 type II toxin-antitoxin system PemK/MazF family toxin -
HV042_RS10045 2085025..2086482 + 1458 WP_004136541.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13666.67 Da        Isoelectric Point: 10.1718

>T166047 WP_049085818.1 NZ_CP058180:2083121-2083474 [Klebsiella grimontii]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKERE

Download         Length: 354 bp

>T166047 NZ_CP074028:c771839-771663 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT166047 WP_004132739.1 NZ_CP058180:2083479-2083781 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp

>AT166047 NZ_CP074028:c771617-771201 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References