Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4979223..4979825 Replicon chromosome
Accession NZ_CP058172
Organism Enterobacter hormaechei strain RHBSTW-00056

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV047_RS24465 Protein ID WP_045308723.1
Coordinates 4979514..4979825 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV047_RS24460 Protein ID WP_032626927.1
Coordinates 4979223..4979513 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV047_RS24445 4976721..4977623 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV047_RS24450 4977620..4978255 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV047_RS24455 4978252..4979181 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV047_RS24460 4979223..4979513 - 291 WP_032626927.1 helix-turn-helix domain-containing protein Antitoxin
HV047_RS24465 4979514..4979825 - 312 WP_045308723.1 toxin HigB-2 Toxin
HV047_RS24470 4979974..4980915 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV047_RS24475 4980960..4981397 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV047_RS24480 4981394..4982275 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV047_RS24485 4982269..4982868 - 600 WP_003861947.1 glucose-1-phosphatase -
HV047_RS24490 4982987..4983787 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -
HV047_RS24495 4983822..4984718 - 897 WP_063201042.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12134.10 Da        Isoelectric Point: 9.4455

>T166029 WP_045308723.1 NZ_CP058172:c4979825-4979514 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNSGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T166029 NZ_CP074024:1842017-1842271 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10685.18 Da        Isoelectric Point: 10.5888

>AT166029 WP_032626927.1 NZ_CP058172:c4979513-4979223 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT166029 NZ_CP074024:1841769-1842020 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References