Detailed information of TA system TA165976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2882392..2883052
• Replicon: chromosome
• Accession: NZ_CP058160
• Organism: Enterobacter hormaechei strain RHBSTW-00083

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HV059_RS13925
• Protein ID: WP_047053529.1
• Coordinates: 2882699..2883052 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2J0Q4Z7
• Locus tag: HV059_RS13920
• Protein ID: WP_017383313.1
• Coordinates: 2882392..2882694 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV059_RS13905	2878562..2879887	+	1326	WP_181238373.1	SidA/IucD/PvdA family monooxygenase	-
HV059_RS13910	2879914..2882103	+	2190	WP_047053531.1	TonB-dependent siderophore receptor	-
HV059_RS13920	2882392..2882694	-	303	WP_017383313.1	helix-turn-helix transcriptional regulator	Antitoxin
HV059_RS13925	2882699..2883052	-	354	WP_047053529.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV059_RS13930	2883243..2884193	-	951	WP_003859532.1	HTH-type transcriptional regulator Cbl	-
HV059_RS13935	2884290..2885207	-	918	WP_003859531.1	nitrogen assimilation transcriptional regulator NAC	-
HV059_RS13945	2885696..2886619	-	924	WP_047053526.1	L,D-transpeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13522.40 Da
• Isoelectric Point: 10.1729

>T165976 WP_047053529.1 NZ_CP058160:c2883052-2882699 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFNPNRTGI
VLCAGNKIGNERRFYDEMLLVADREYTRWLNTLKERN

Nucleotide

• Length: 354 bp

>T165976 NZ_CP074009:c17272-16892 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGCCACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11028.85 Da
• Isoelectric Point: 6.4727

>AT165976 WP_017383313.1 NZ_CP058160:c2882694-2882392 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT165976 NZ_CP074009:c17493-17272 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A2J0Q4Z7