Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 20929..21430 Replicon plasmid pRHBSTW-00138_3
Accession NZ_CP058133
Organism Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2J4ZS98
Locus tag HV092_RS27220 Protein ID WP_019725129.1
Coordinates 21155..21430 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2J4ZS71
Locus tag HV092_RS27215 Protein ID WP_025987695.1
Coordinates 20929..21174 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV092_RS27185 16193..16339 + 147 WP_004152750.1 hypothetical protein -
HV092_RS27190 16390..17223 + 834 WP_004152751.1 type I restriction-modification system subunit M -
HV092_RS27195 18043..18864 + 822 WP_004152492.1 DUF945 domain-containing protein -
HV092_RS27200 18897..19226 + 330 WP_011977736.1 hypothetical protein -
HV092_RS27205 19259..19744 - 486 WP_001568108.1 transglycosylase SLT domain-containing protein -
HV092_RS27210 20531..20692 - 162 WP_162870772.1 hypothetical protein -
HV092_RS27215 20929..21174 + 246 WP_025987695.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HV092_RS27220 21155..21430 + 276 WP_019725129.1 Txe/YoeB family addiction module toxin Toxin
HV092_RS27225 21678..21857 + 180 Protein_27 replicase -
HV092_RS27230 21924..22628 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HV092_RS27235 22678..25611 + 2934 Protein_29 Tn3 family transposase -
HV092_RS27240 25785..26051 - 267 WP_058657698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sul1 / qacE / ant(3'')-Ia / blaOXA-10 / ant(2'')-Ia - 1..55155 55155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10902.41 Da        Isoelectric Point: 10.2004

>T165885 WP_019725129.1 NZ_CP058133:21155-21430 [Klebsiella quasipneumoniae]
MSKWNIKFTRNGADDLNYWRDTDKKKFERIRQLLLSIEADPLTGIGKPERLRHHKDPALYSRRIDQSHRLVYSIQNGEII
IYAARYHYGDK

Download         Length: 276 bp

>T165885 NZ_CP073994:2401365-2402687 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9361.49 Da        Isoelectric Point: 4.4269

>AT165885 WP_025987695.1 NZ_CP058133:20929-21174 [Klebsiella quasipneumoniae]
MHAINFTDARKHFAETMKRVTDDAEPVRVMRRDAPDIVMIDAGEYEALIETVYLFSNPANAEHINESMKQAERGEFVEVE
Y

Download         Length: 246 bp

>AT165885 NZ_CP073994:2401099-2401365 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZS98

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZS71

References