Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1257447..1258174 Replicon chromosome
Accession NZ_CP058128
Organism Enterobacter hormaechei strain RHBSTW-00140

Toxin (Protein)


Gene name higB Uniprot ID A0A9E6WR45
Locus tag HV094_RS06115 Protein ID WP_045623285.1
Coordinates 1257863..1258174 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV094_RS06110 Protein ID WP_045623284.1
Coordinates 1257447..1257866 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV094_RS06075 1253044..1253271 + 228 WP_124304273.1 hypothetical protein -
HV094_RS06080 1254073..1254267 + 195 Protein_1178 hypothetical protein -
HV094_RS06085 1254280..1255131 + 852 Protein_1179 RHS domain-containing protein -
HV094_RS06090 1255128..1255610 + 483 WP_063139119.1 immunity 26/phosphotriesterase HocA family protein -
HV094_RS06095 1255824..1256123 + 300 WP_124304274.1 hypothetical protein -
HV094_RS06100 1256127..1256369 - 243 WP_124304275.1 hypothetical protein -
HV094_RS06105 1256733..1257179 + 447 WP_045623318.1 hypothetical protein -
HV094_RS06110 1257447..1257866 - 420 WP_045623284.1 helix-turn-helix domain-containing protein Antitoxin
HV094_RS06115 1257863..1258174 - 312 WP_045623285.1 type II toxin-antitoxin system HigB family toxin Toxin
HV094_RS06120 1258395..1258805 - 411 WP_023299534.1 ASCH domain-containing protein -
HV094_RS06125 1259006..1259461 - 456 WP_023305643.1 hypothetical protein -
HV094_RS06130 1260165..1260377 + 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
HV094_RS06135 1260604..1261500 - 897 WP_045623287.1 LysR family transcriptional regulator -
HV094_RS06140 1261606..1262385 + 780 WP_088581799.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12453.32 Da        Isoelectric Point: 9.8331

>T165854 WP_045623285.1 NZ_CP058128:c1258174-1257863 [Enterobacter hormaechei]
MPAVSRAPFDAATRHFPIQELALEDLYWVLKGEHYPSPDDMRKRFPSRERMKYREKWWVIDVGGGYLRVMLFTDFERGKL
FIKHTSTHADYDKLTDLYRRKKE

Download         Length: 312 bp

>T165854 NZ_CP073986:c44792-44505 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGATTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15522.56 Da        Isoelectric Point: 4.7722

>AT165854 WP_045623284.1 NZ_CP058128:c1257866-1257447 [Enterobacter hormaechei]
MNFSAAIKAANDLTRELPFLGSSPSRQDYEDAMGLVEYLIEHDPDSPLVEMLTAKIDKYENESPEFAEFNARVASIPSGV
ALLRTLMDQYHLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVQVSAFVGN

Download         Length: 420 bp

>AT165854 NZ_CP073986:c45040-44789 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References