Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 43050..43700 Replicon chromosome
Accession NZ_CP058112
Organism Klebsiella grimontii strain RHBSTW-00181

Toxin (Protein)


Gene name higB Uniprot ID A0A9E1GCI7
Locus tag HV112_RS00210 Protein ID WP_024360564.1
Coordinates 43050..43391 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1GGB7
Locus tag HV112_RS00215 Protein ID WP_024360565.1
Coordinates 43401..43700 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV112_RS00195 39283..40602 + 1320 WP_004133107.1 MFS transporter -
HV112_RS00200 40748..42139 + 1392 WP_004126843.1 hexose-6-phosphate:phosphate antiporter -
HV112_RS00205 42351..42803 + 453 WP_024360563.1 DUF1198 domain-containing protein -
HV112_RS00210 43050..43391 + 342 WP_024360564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV112_RS00215 43401..43700 + 300 WP_024360565.1 helix-turn-helix transcriptional regulator Antitoxin
HV112_RS00220 43818..44999 + 1182 WP_024360566.1 purine ribonucleoside efflux pump NepI -
HV112_RS00225 45118..46497 - 1380 WP_004133118.1 carbohydrate porin -
HV112_RS00230 46600..46902 - 303 WP_004855598.1 PTS lactose/cellobiose transporter subunit IIA -
HV112_RS00235 47010..48335 - 1326 WP_004133122.1 PTS sugar transporter subunit IIC -
HV112_RS00240 48347..48658 - 312 WP_049131329.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-83)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13091.97 Da        Isoelectric Point: 5.7558

>T165817 WP_024360564.1 NZ_CP058112:43050-43391 [Klebsiella grimontii]
MWDVETTEVFDKWFEAQIEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHRGSPIRAFFVFDPSRRGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T165817 NZ_CP073981:c2236443-2235979 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10994.92 Da        Isoelectric Point: 9.7256

>AT165817 WP_024360565.1 NZ_CP058112:43401-43700 [Klebsiella grimontii]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVVALG
GELSIDVKLPTGKRIAFHL

Download         Length: 300 bp

>AT165817 NZ_CP073981:c2236778-2236443 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References