Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2208811..2209373 Replicon chromosome
Accession NZ_CP058057
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVV54_RS10800 Protein ID WP_104919749.1
Coordinates 2209095..2209373 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVV54_RS10795 Protein ID WP_000781370.1
Coordinates 2208811..2209095 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS10780 2204170..2207217 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HVV54_RS10785 2207230..2208114 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
HVV54_RS10790 2208107..2208760 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVV54_RS10795 2208811..2209095 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVV54_RS10800 2209095..2209373 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVV54_RS10805 2209559..2210569 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVV54_RS10810 2210703..2212400 - 1698 WP_181203469.1 malate dehydrogenase -
HVV54_RS10815 2212557..2212694 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVV54_RS10820 2212796..2213011 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVV54_RS10825 2213353..2213784 + 432 WP_000152305.1 peroxiredoxin OsmC -
HVV54_RS10830 2213845..2213985 + 141 WP_181203495.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T165802 WP_104919749.1 NZ_CP058057:c2209373-2209095 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165802 NZ_CP073974:c1925941-1925543 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165802 WP_000781370.1 NZ_CP058057:c2209095-2208811 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165802 NZ_CP073974:c1926237-1925944 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References