Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 870264..870510 Replicon chromosome
Accession NZ_CP058057
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag HVV54_RS04230 Protein ID WP_000956458.1
Coordinates 870358..870510 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 870264..870316 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS04215 865772..867571 + 1800 WP_181203169.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
HVV54_RS04220 867571..869283 + 1713 WP_115738177.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
HVV54_RS04225 869357..870091 + 735 WP_181203170.1 phosphoadenosine phosphosulfate reductase -
- 870264..870316 - 53 - - Antitoxin
HVV54_RS04230 870358..870510 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
HVV54_RS04235 870746..873403 + 2658 WP_002431960.1 CRISPR-associated helicase/endonuclease Cas3 -
HVV54_RS04240 873501..875063 + 1563 WP_181203171.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T165790 WP_000956458.1 NZ_CP058057:870358-870510 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T165790 NZ_CP073963:c110329-110024 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 53 bp

>AT165790 NZ_CP058057:c870316-870264 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References