Detailed information of TA system TA165787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 437820..438619
• Replicon: chromosome
• Accession: NZ_CP058057
• Organism: Escherichia fergusonii strain RHB02-C22

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: F0JQM9
• Locus tag: HVV54_RS02105
• Protein ID: WP_000347270.1
• Coordinates: 437820..438284 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: HVV54_RS02110
• Protein ID: WP_104919918.1
• Coordinates: 438284..438619 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVV54_RS02075	432821..433255	-	435	WP_032303830.1	PTS sugar transporter subunit IIA	-
HVV54_RS02080	433273..434151	-	879	WP_001295548.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
HVV54_RS02085	434141..434920	-	780	WP_000406214.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
HVV54_RS02090	434931..435404	-	474	WP_032303829.1	PTS N-acetylgalactosamine transporter subunit IIB	-
HVV54_RS02095	435427..436707	-	1281	WP_181203097.1	tagatose-bisphosphate aldolase subunit KbaZ	-
HVV54_RS02100	436956..437765	+	810	WP_000072187.1	aga operon transcriptional regulator AgaR	-
HVV54_RS02105	437820..438284	-	465	WP_000347270.1	type II toxin-antitoxin system ribonuclease toxin YhaV	Toxin
HVV54_RS02110	438284..438619	-	336	WP_104919918.1	type II toxin-antitoxin system antitoxin PrlF	Antitoxin
HVV54_RS02115	438768..440339	-	1572	WP_181203098.1	galactarate dehydratase	-
HVV54_RS02120	440810..441580	+	771	WP_001058567.1	2-dehydro-3-deoxyglucarate aldolase	-
HVV54_RS02125	441605..442495	+	891	WP_000178100.1	2-hydroxy-3-oxopropionate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-150)

Antitoxin

• PrlF antitoxin (14-110)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17806.22 Da
• Isoelectric Point: 9.6924

>T165787 WP_000347270.1 NZ_CP058057:c438284-437820 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Nucleotide

• Length: 465 bp

>T165787 NZ_CP073962:c4271736-4271386 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12349.93 Da
• Isoelectric Point: 4.5392

>AT165787 WP_104919918.1 NZ_CP058057:c438619-438284 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGRKLVAGMDVNIDDEIGDDE

Nucleotide

• Length: 336 bp

>AT165787 NZ_CP073962:c4271981-4271730 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0V9NQ90