Detailed information of TA system TA165763

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 571991..572249
• Replicon: chromosome
• Accession: NZ_CP057918
• Organism: Escherichia fergusonii strain RHB10-C04

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVW38_RS02880
• Protein ID: WP_000935262.1
• Coordinates: 571991..572200 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	572192..572249 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVW38_RS02860	567057..567644	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVW38_RS02865	567678..568244	-	567	WP_000528529.1	acetate uptake transporter	-
HVW38_RS02870	568752..570668	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVW38_RS02875	570757..571887	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVW38_RS02880	571991..572200	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	572192..572249	+	58	-	-	Antitoxin
HVW38_RS02885	572684..573850	+	1167	WP_046076806.1	Na+/H+ antiporter NhaA	-
HVW38_RS02890	573918..574817	+	900	WP_000019050.1	transcriptional activator NhaR	-
HVW38_RS02895	574913..575176	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVW38_RS02900	575279..575497	+	219	WP_046076805.1	DUF2575 family protein	-
HVW38_RS02905	575505..576446	+	942	WP_046076804.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165763 WP_000935262.1 NZ_CP057918:c572200-571991 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165763 NZ_CP073958:4264533-4264910 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165763 NZ_CP057918:572192-572249 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin