Detailed information of TA system TA165694

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3546073..3546331
• Replicon: chromosome
• Accession: NZ_CP057692
• Organism: Escherichia fergusonii strain RHB17-C11

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVX29_RS17175
• Protein ID: WP_077626863.1
• Coordinates: 3546073..3546282 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3546274..3546331 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX29_RS17155	3541139..3541726	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
HVX29_RS17160	3541760..3542326	-	567	WP_000528529.1	acetate uptake transporter	-
HVX29_RS17165	3542833..3544749	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVX29_RS17170	3544838..3545968	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVX29_RS17175	3546073..3546282	-	210	WP_077626863.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3546274..3546331	+	58	-	-	Antitoxin
HVX29_RS17180	3546766..3547932	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
HVX29_RS17185	3548000..3548899	+	900	WP_000019050.1	transcriptional activator NhaR	-
HVX29_RS17190	3548995..3549258	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVX29_RS17195	3549361..3549579	+	219	WP_012599853.1	DUF2575 family protein	-
HVX29_RS17200	3549587..3550528	+	942	WP_000767348.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7728.25 Da
• Isoelectric Point: 9.3680

>T165694 WP_077626863.1 NZ_CP057692:c3546282-3546073 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICVTAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165694 NZ_CP073946:c4323202-4323029 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT165694 NZ_CP057692:3546274-3546331 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin