Detailed information of TA system TA165692

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2613495..2613752
• Replicon: chromosome
• Accession: NZ_CP057692
• Organism: Escherichia fergusonii strain RHB17-C11

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: HVX29_RS12670
• Protein ID: WP_001135731.1
• Coordinates: 2613495..2613647 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2613704..2613752 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX29_RS12645	2609359..2610069	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVX29_RS12650	2610507..2611877	+	1371	WP_000184983.1	MFS transporter	-
HVX29_RS12655	2612127..2612417	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVX29_RS12660	2612699..2612911	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVX29_RS12665	2612965..2613336	-	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
HVX29_RS12670	2613495..2613647	-	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
-	2613704..2613752	+	49	-	-	Antitoxin
HVX29_RS12675	2613969..2616038	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVX29_RS12680	2616048..2616959	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVX29_RS12685	2617055..2617354	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVX29_RS12690	2617526..2618521	+	996	WP_002432855.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T165692 WP_001135731.1 NZ_CP057692:c2613647-2613495 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165692 NZ_CP073946:c4274381-4274004 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTATTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGCC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG

Antitoxin

Nucleotide

• Length: 49 bp

>AT165692 NZ_CP057692:2613704-2613752 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin