Detailed information of TA system TA165688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokA/Ldr(toxin)
• Location: 2583660..2583879
• Replicon: chromosome
• Accession: NZ_CP057692
• Organism: Escherichia fergusonii strain RHB17-C11

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A829L523
• Locus tag: HVX29_RS12525
• Protein ID: WP_000170738.1
• Coordinates: 2583660..2583767 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2583816..2583879 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX29_RS12495	2578709..2578897	-	189	WP_001063310.1	YhjR family protein	-
HVX29_RS12500	2579184..2580743	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVX29_RS12505	2580740..2580931	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVX29_RS12510	2580928..2582607	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVX29_RS12515	2582694..2582801	-	108	WP_000170746.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVX29_RS12520	2583177..2583284	-	108	WP_002431793.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVX29_RS12525	2583660..2583767	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2583816..2583879	+	64	NuclAT_17	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_17	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_17	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_17	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_19	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_19	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_19	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_19	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_21	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_21	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_21	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_21	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_23	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_23	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_23	-	Antitoxin
-	2583816..2583879	+	64	NuclAT_23	-	Antitoxin
-	2583816..2583881	+	66	NuclAT_12	-	-
-	2583816..2583881	+	66	NuclAT_12	-	-
-	2583816..2583881	+	66	NuclAT_12	-	-
-	2583816..2583881	+	66	NuclAT_12	-	-
-	2583816..2583881	+	66	NuclAT_14	-	-
-	2583816..2583881	+	66	NuclAT_14	-	-
-	2583816..2583881	+	66	NuclAT_14	-	-
-	2583816..2583881	+	66	NuclAT_14	-	-
HVX29_RS12530	2584132..2584239	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	2584288..2584351	+	64	NuclAT_16	-	-
-	2584288..2584351	+	64	NuclAT_16	-	-
-	2584288..2584351	+	64	NuclAT_16	-	-
-	2584288..2584351	+	64	NuclAT_16	-	-
-	2584288..2584351	+	64	NuclAT_18	-	-
-	2584288..2584351	+	64	NuclAT_18	-	-
-	2584288..2584351	+	64	NuclAT_18	-	-
-	2584288..2584351	+	64	NuclAT_18	-	-
-	2584288..2584351	+	64	NuclAT_20	-	-
-	2584288..2584351	+	64	NuclAT_20	-	-
-	2584288..2584351	+	64	NuclAT_20	-	-
-	2584288..2584351	+	64	NuclAT_20	-	-
-	2584288..2584351	+	64	NuclAT_22	-	-
-	2584288..2584351	+	64	NuclAT_22	-	-
-	2584288..2584351	+	64	NuclAT_22	-	-
-	2584288..2584351	+	64	NuclAT_22	-	-
-	2584288..2584353	+	66	NuclAT_11	-	-
-	2584288..2584353	+	66	NuclAT_11	-	-
-	2584288..2584353	+	66	NuclAT_11	-	-
-	2584288..2584353	+	66	NuclAT_11	-	-
-	2584288..2584353	+	66	NuclAT_13	-	-
-	2584288..2584353	+	66	NuclAT_13	-	-
-	2584288..2584353	+	66	NuclAT_13	-	-
-	2584288..2584353	+	66	NuclAT_13	-	-
HVX29_RS12535	2584676..2585872	+	1197	WP_001016304.1	methionine gamma-lyase	-
HVX29_RS12540	2586122..2587420	+	1299	WP_001152712.1	amino acid permease	-
HVX29_RS12545	2587436..2588647	-	1212	WP_181812673.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3864.67 Da
• Isoelectric Point: 9.0157

>T165688 WP_000170738.1 NZ_CP057692:c2583767-2583660 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165688 NZ_CP073946:3563156-3563374 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165688 NZ_CP057692:2583816-2583879 [Escherichia fergusonii]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A829L523

Antitoxin