Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 487108..487670 Replicon chromosome
Accession NZ_CP057692
Organism Escherichia fergusonii strain RHB17-C11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVX29_RS02420 Protein ID WP_000605678.1
Coordinates 487392..487670 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVX29_RS02415 Protein ID WP_000781370.1
Coordinates 487108..487392 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX29_RS02400 482467..485514 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HVX29_RS02405 485527..486411 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
HVX29_RS02410 486404..487057 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVX29_RS02415 487108..487392 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVX29_RS02420 487392..487670 - 279 WP_000605678.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX29_RS02425 487856..488866 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVX29_RS02430 489001..490698 - 1698 WP_000433464.1 malate dehydrogenase -
HVX29_RS02435 490855..490992 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVX29_RS02440 491094..491309 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVX29_RS02445 491652..492083 + 432 WP_000152299.1 peroxiredoxin OsmC -
HVX29_RS02450 492144..492284 + 141 WP_114091452.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10478.07 Da        Isoelectric Point: 6.8675

>T165682 WP_000605678.1 NZ_CP057692:c487670-487392 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWLITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165682 NZ_CP073946:1044352-1044687 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165682 WP_000781370.1 NZ_CP057692:c487392-487108 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165682 NZ_CP073946:1044104-1044352 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References