Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4037177..4037856 Replicon chromosome
Accession NZ_CP057681
Organism Escherichia fergusonii strain RHB18-C04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVX35_RS19720 Protein ID WP_181198810.1
Coordinates 4037177..4037479 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVX35_RS19725 Protein ID WP_000806441.1
Coordinates 4037515..4037856 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX35_RS19695 4032553..4034205 + 1653 WP_160193899.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
HVX35_RS19700 4034243..4034746 - 504 WP_000667001.1 hypothetical protein -
HVX35_RS19705 4034743..4035543 - 801 WP_181198808.1 hypothetical protein -
HVX35_RS19710 4035567..4036046 - 480 WP_181198809.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
HVX35_RS19715 4036250..4037044 - 795 WP_046081753.1 TraB/GumN family protein -
HVX35_RS19720 4037177..4037479 + 303 WP_181198810.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX35_RS19725 4037515..4037856 + 342 WP_000806441.1 HigA family addiction module antidote protein Antitoxin
HVX35_RS19730 4037970..4040474 - 2505 WP_181198811.1 copper-exporting P-type ATPase CopA -
HVX35_RS19735 4040781..4042070 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11753.34 Da        Isoelectric Point: 10.3339

>T165668 WP_181198810.1 NZ_CP057681:4037177-4037479 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAAELYLDPHNY

Download         Length: 303 bp

>T165668 NZ_CP073943:2587020-2587127 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13143.01 Da        Isoelectric Point: 5.2345

>AT165668 WP_000806441.1 NZ_CP057681:4037515-4037856 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVADYLARREERAKNVA

Download         Length: 342 bp

>AT165668 NZ_CP073943:c2586973-2586907 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References