Detailed information of TA system TA165657

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 2535322..2535541
• Replicon: chromosome
• Accession: NZ_CP057681
• Organism: Escherichia fergusonii strain RHB18-C04

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A826RQE3
• Locus tag: HVX35_RS12350
• Protein ID: WP_000170746.1
• Coordinates: 2535322..2535429 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	2535478..2535541 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX35_RS12325	2530558..2531325	-	768	WP_181198551.1	cellulose biosynthesis protein BcsQ	-
HVX35_RS12330	2531337..2531525	-	189	WP_001063310.1	YhjR family protein	-
HVX35_RS12335	2531812..2533371	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVX35_RS12340	2533368..2533559	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVX35_RS12345	2533556..2535235	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVX35_RS12350	2535322..2535429	-	108	WP_000170746.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2535478..2535541	+	64	NuclAT_13	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_13	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_13	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_13	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_14	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_14	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_14	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_14	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_15	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_15	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_15	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_15	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_16	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_16	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_16	-	Antitoxin
-	2535478..2535541	+	64	NuclAT_16	-	Antitoxin
-	2535478..2535543	+	66	NuclAT_10	-	-
-	2535478..2535543	+	66	NuclAT_10	-	-
-	2535478..2535543	+	66	NuclAT_10	-	-
-	2535478..2535543	+	66	NuclAT_10	-	-
-	2535478..2535543	+	66	NuclAT_11	-	-
-	2535478..2535543	+	66	NuclAT_11	-	-
-	2535478..2535543	+	66	NuclAT_11	-	-
-	2535478..2535543	+	66	NuclAT_11	-	-
HVX35_RS12355	2535865..2537061	+	1197	WP_104920204.1	methionine gamma-lyase	-
HVX35_RS12360	2537311..2538609	+	1299	WP_181198552.1	amino acid permease	-
HVX35_RS12365	2538625..2539836	-	1212	WP_181198553.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3912.73 Da
• Isoelectric Point: 9.0157

>T165657 WP_000170746.1 NZ_CP057681:c2535429-2535322 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVITGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165657 NZ_CP073943:718952-719329 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165657 NZ_CP057681:2535478-2535541 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A826RQE3

Antitoxin