Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 484135..484697 Replicon chromosome
Accession NZ_CP057681
Organism Escherichia fergusonii strain RHB18-C04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVX35_RS02410 Protein ID WP_104919749.1
Coordinates 484419..484697 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag HVX35_RS02405 Protein ID WP_000781370.1
Coordinates 484135..484419 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX35_RS02390 479494..482541 + 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -
HVX35_RS02395 482554..483438 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
HVX35_RS02400 483431..484084 + 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
HVX35_RS02405 484135..484419 - 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
HVX35_RS02410 484419..484697 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX35_RS02415 484883..485893 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
HVX35_RS02420 486028..487725 - 1698 WP_000433464.1 malate dehydrogenase -
HVX35_RS02425 487882..488019 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
HVX35_RS02430 488121..488336 - 216 WP_000495766.1 biofilm-dependent modulation protein -
HVX35_RS02435 488679..489110 + 432 WP_000152299.1 peroxiredoxin OsmC -
HVX35_RS02440 489171..489311 + 141 WP_109043809.1 omptin family outer membrane protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T165651 WP_104919749.1 NZ_CP057681:c484697-484419 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165651 NZ_CP073939:c4195167-4194781 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT165651 WP_000781370.1 NZ_CP057681:c484419-484135 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT165651 NZ_CP073939:c4195706-4195197 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGTTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References