Detailed information of TA system TA165635

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3850205..3850451
• Replicon: chromosome
• Accession: NZ_CP057657
• Organism: Escherichia fergusonii strain RHB19-C05

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: S1PD89
• Locus tag: HVX45_RS18645
• Protein ID: WP_000956458.1
• Coordinates: 3850299..3850451 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	3850205..3850257 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX45_RS18630	3845713..3847512	+	1800	WP_000211943.1	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	-
HVX45_RS18635	3847512..3849224	+	1713	WP_046083135.1	assimilatory sulfite reductase (NADPH) hemoprotein subunit	-
HVX45_RS18640	3849298..3850032	+	735	WP_046083134.1	phosphoadenosine phosphosulfate reductase	-
-	3850205..3850257	-	53	-	-	Antitoxin
HVX45_RS18645	3850299..3850451	+	153	WP_000956458.1	type I toxin-antitoxin system Hok family toxin	Toxin
HVX45_RS18650	3850687..3853344	+	2658	WP_181672359.1	CRISPR-associated helicase Cas3'	-
HVX45_RS18655	3853442..3855004	+	1563	WP_046083149.1	type I-E CRISPR-associated protein Cse1/CasA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3841004..3850451	9447

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5558.77 Da
• Isoelectric Point: 7.6757

>T165635 WP_000956458.1 NZ_CP057657:3850299-3850451 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Nucleotide

• Length: 153 bp

>T165635 NZ_CP073939:268085-268360 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Nucleotide

• Length: 53 bp

>AT165635 NZ_CP057657:c3850257-3850205 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Structures

Toxin

• AlphaFold DB: A0A4P7TJ83

Antitoxin