Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3546880..3547138 Replicon chromosome
Accession NZ_CP057657
Organism Escherichia fergusonii strain RHB19-C05

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag HVX45_RS17265 Protein ID WP_000935262.1
Coordinates 3546880..3547089 (-) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3547081..3547138 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX45_RS17245 3541946..3542533 + 588 WP_046083027.1 molybdopterin adenylyltransferase -
HVX45_RS17250 3542567..3543133 - 567 WP_000528529.1 acetate uptake transporter -
HVX45_RS17255 3543641..3545557 + 1917 WP_000516135.1 molecular chaperone DnaK -
HVX45_RS17260 3545646..3546776 + 1131 WP_001118464.1 molecular chaperone DnaJ -
HVX45_RS17265 3546880..3547089 - 210 WP_000935262.1 type I toxin-antitoxin system Hok family toxin Toxin
- 3547081..3547138 + 58 - - Antitoxin
HVX45_RS17270 3547573..3548739 + 1167 WP_046076806.1 Na+/H+ antiporter NhaA -
HVX45_RS17275 3548807..3549706 + 900 WP_000019049.1 transcriptional activator NhaR -
HVX45_RS17280 3549802..3550065 - 264 WP_001274021.1 30S ribosomal protein S20 -
HVX45_RS17285 3550168..3550386 + 219 WP_012599853.1 DUF2575 family protein -
HVX45_RS17290 3550394..3551335 + 942 WP_046081994.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7742.28 Da        Isoelectric Point: 9.3680

>T165632 WP_000935262.1 NZ_CP057657:c3547089-3546880 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T165632 NZ_CP073936:c4269269-4269096 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 58 bp

>AT165632 NZ_CP057657:3547081-3547138 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References