Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1076763..1077265 Replicon chromosome
Accession NZ_CP057657
Organism Escherichia fergusonii strain RHB19-C05

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HVX45_RS05320 Protein ID WP_046083399.1
Coordinates 1076763..1077017 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HVX45_RS05325 Protein ID WP_001259255.1
Coordinates 1077014..1077265 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX45_RS05290 1071778..1072005 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
HVX45_RS05295 1072019..1073077 - 1059 WP_046080827.1 transport protein YeeE -
HVX45_RS05300 1073257..1074615 - 1359 WP_000019201.1 putrescine/proton symporter PlaP -
HVX45_RS05305 1074605..1074667 - 63 WP_010723108.1 membrane protein YoeI -
HVX45_RS05310 1074881..1075810 - 930 WP_000803361.1 LysR family transcriptional regulator -
HVX45_RS05315 1075856..1076680 - 825 WP_000754726.1 SDR family oxidoreductase -
HVX45_RS05320 1076763..1077017 - 255 WP_046083399.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HVX45_RS05325 1077014..1077265 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HVX45_RS05330 1077549..1077599 + 51 WP_001364200.1 his operon leader peptide -
HVX45_RS05335 1077745..1078644 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
HVX45_RS05340 1078650..1079954 + 1305 WP_046083400.1 histidinol dehydrogenase -
HVX45_RS05345 1079951..1081021 + 1071 WP_046083401.1 histidinol-phosphate transaminase -
HVX45_RS05350 1081021..1082088 + 1068 WP_046083402.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10201.62 Da        Isoelectric Point: 8.0353

>T165620 WP_046083399.1 NZ_CP057657:c1077017-1076763 [Escherichia fergusonii]
VKLIWSEESWDDYMYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T165620 NZ_CP073936:1765931-1766185 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT165620 WP_001259255.1 NZ_CP057657:c1077265-1077014 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT165620 NZ_CP073936:1765683-1765934 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References