Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4340561..4341377 Replicon chromosome
Accession NZ_CP057632
Organism Citrobacter sp. RHB20-C15

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3S7D6F0
Locus tag HVX63_RS20810 Protein ID WP_042999109.1
Coordinates 4340561..4341037 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A3Q8DNJ3
Locus tag HVX63_RS20815 Protein ID WP_042999108.1
Coordinates 4341042..4341377 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX63_RS20790 4335666..4336409 - 744 WP_044257300.1 molecular chaperone -
HVX63_RS20795 4336452..4338926 - 2475 WP_044257386.1 fimbria/pilus outer membrane usher protein -
HVX63_RS20800 4338990..4339439 - 450 WP_086513030.1 type 1 fimbrial protein -
HVX63_RS20805 4339607..4340137 - 531 WP_042999110.1 type 1 fimbrial protein -
HVX63_RS20810 4340561..4341037 - 477 WP_042999109.1 type II toxin-antitoxin system YhaV family toxin Toxin
HVX63_RS20815 4341042..4341377 - 336 WP_042999108.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HVX63_RS20820 4341592..4342128 - 537 WP_042999107.1 ferredoxin-type protein NapF -
HVX63_RS20825 4342125..4342721 - 597 WP_042999106.1 molecular chaperone -
HVX63_RS20830 4342766..4343539 - 774 WP_044257303.1 dimethyl sulfoxide reductase anchor subunit -
HVX63_RS20835 4343532..4344158 - 627 WP_044257304.1 dimethylsulfoxide reductase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(15-110)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18237.84 Da        Isoelectric Point: 8.8956

>T165609 WP_042999109.1 NZ_CP057632:c4341037-4340561 [Citrobacter sp. RHB20-C15]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYRPGDSIGKAY
TDWSRAKFGGGRYRLFFRYSLESKIIVIAWVNDEGPLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQACQNDGKEHL

Download         Length: 477 bp

>T165609 NZ_CP073932:c3597200-3596802 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.83 Da        Isoelectric Point: 4.1876

>AT165609 WP_042999108.1 NZ_CP057632:c4341377-4341042 [Citrobacter sp. RHB20-C15]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Download         Length: 336 bp

>AT165609 NZ_CP073932:c3597496-3597203 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7D6F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DNJ3

References