Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4339496..4340312 Replicon chromosome
Accession NZ_CP057630
Organism Citrobacter sp. RHB20-C16

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3S7D6F0
Locus tag HVX64_RS20810 Protein ID WP_042999109.1
Coordinates 4339496..4339972 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A3Q8DNJ3
Locus tag HVX64_RS20815 Protein ID WP_042999108.1
Coordinates 4339977..4340312 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX64_RS20790 4334601..4335344 - 744 WP_044257300.1 molecular chaperone -
HVX64_RS20795 4335387..4337861 - 2475 WP_044257386.1 fimbria/pilus outer membrane usher protein -
HVX64_RS20800 4337925..4338374 - 450 WP_086513030.1 type 1 fimbrial protein -
HVX64_RS20805 4338542..4339072 - 531 WP_042999110.1 type 1 fimbrial protein -
HVX64_RS20810 4339496..4339972 - 477 WP_042999109.1 type II toxin-antitoxin system YhaV family toxin Toxin
HVX64_RS20815 4339977..4340312 - 336 WP_042999108.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HVX64_RS20820 4340527..4341063 - 537 WP_042999107.1 ferredoxin-type protein NapF -
HVX64_RS20825 4341060..4341656 - 597 WP_042999106.1 molecular chaperone -
HVX64_RS20830 4341701..4342474 - 774 WP_044257303.1 dimethyl sulfoxide reductase anchor subunit -
HVX64_RS20835 4342467..4343093 - 627 WP_044257304.1 dimethylsulfoxide reductase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(15-110)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18237.84 Da        Isoelectric Point: 8.8956

>T165590 WP_042999109.1 NZ_CP057630:c4339972-4339496 [Citrobacter sp. RHB20-C16]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYRPGDSIGKAY
TDWSRAKFGGGRYRLFFRYSLESKIIVIAWVNDEGPLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQACQNDGKEHL

Download         Length: 477 bp

>T165590 NZ_CP073929:c4291886-4291713 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.83 Da        Isoelectric Point: 4.1876

>AT165590 WP_042999108.1 NZ_CP057630:c4340312-4339977 [Citrobacter sp. RHB20-C16]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Download         Length: 336 bp

>AT165590 NZ_CP073929:c4292210-4291914 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7D6F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DNJ3

References