Detailed information of TA system TA165537

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokC/Ldr(toxin)
• Location: 4270873..4271092
• Replicon: chromosome
• Accession: NZ_CP057565
• Organism: Escherichia fergusonii strain RHB23-C01

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVX91_RS20420
• Protein ID: WP_001295224.1
• Coordinates: 4270873..4270980 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4271029..4271092 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX91_RS20390	4265916..4267475	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVX91_RS20395	4267472..4267663	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVX91_RS20400	4267660..4269339	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVX91_RS20405	4269426..4269533	-	108	WP_000170746.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4269591..4269645	+	55	NuclAT_16	-	-
-	4269591..4269645	+	55	NuclAT_16	-	-
-	4269591..4269645	+	55	NuclAT_16	-	-
-	4269591..4269645	+	55	NuclAT_16	-	-
-	4269591..4269645	+	55	NuclAT_18	-	-
-	4269591..4269645	+	55	NuclAT_18	-	-
-	4269591..4269645	+	55	NuclAT_18	-	-
-	4269591..4269645	+	55	NuclAT_18	-	-
-	4269591..4269645	+	55	NuclAT_20	-	-
-	4269591..4269645	+	55	NuclAT_20	-	-
-	4269591..4269645	+	55	NuclAT_20	-	-
-	4269591..4269645	+	55	NuclAT_20	-	-
-	4269591..4269645	+	55	NuclAT_22	-	-
-	4269591..4269645	+	55	NuclAT_22	-	-
-	4269591..4269645	+	55	NuclAT_22	-	-
-	4269591..4269645	+	55	NuclAT_22	-	-
-	4269591..4269647	+	57	NuclAT_12	-	-
-	4269591..4269647	+	57	NuclAT_12	-	-
-	4269591..4269647	+	57	NuclAT_12	-	-
-	4269591..4269647	+	57	NuclAT_12	-	-
-	4269591..4269647	+	57	NuclAT_14	-	-
-	4269591..4269647	+	57	NuclAT_14	-	-
-	4269591..4269647	+	57	NuclAT_14	-	-
-	4269591..4269647	+	57	NuclAT_14	-	-
HVX91_RS20410	4269908..4270015	-	108	WP_072132476.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVX91_RS20415	4270390..4270497	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVX91_RS20420	4270873..4270980	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4271029..4271092	+	64	NuclAT_15	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_15	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_15	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_15	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_17	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_17	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_17	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_17	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_19	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_19	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_19	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_19	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_21	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_21	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_21	-	Antitoxin
-	4271029..4271092	+	64	NuclAT_21	-	Antitoxin
-	4271029..4271094	+	66	NuclAT_11	-	-
-	4271029..4271094	+	66	NuclAT_11	-	-
-	4271029..4271094	+	66	NuclAT_11	-	-
-	4271029..4271094	+	66	NuclAT_11	-	-
-	4271029..4271094	+	66	NuclAT_13	-	-
-	4271029..4271094	+	66	NuclAT_13	-	-
-	4271029..4271094	+	66	NuclAT_13	-	-
-	4271029..4271094	+	66	NuclAT_13	-	-
HVX91_RS20425	4271416..4272612	+	1197	WP_001016304.1	methionine gamma-lyase	-
HVX91_RS20430	4272862..4274160	+	1299	WP_001152712.1	amino acid permease	-
HVX91_RS20435	4274176..4275387	-	1212	WP_002431795.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T165537 WP_001295224.1 NZ_CP057565:c4270980-4270873 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165537 NZ_CP073924:2440559-2441881 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
ATTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165537 NZ_CP057565:4271029-4271092 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin