Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1195701..1196380 Replicon chromosome
Accession NZ_CP057565
Organism Escherichia fergusonii strain RHB23-C01

Toxin (Protein)


Gene name higB Uniprot ID A0A0A1A1R1
Locus tag HVX91_RS05740 Protein ID WP_000057541.1
Coordinates 1195701..1196003 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag HVX91_RS05745 Protein ID WP_000806442.1
Coordinates 1196039..1196380 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX91_RS05715 1191077..1192729 + 1653 WP_181591242.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
HVX91_RS05720 1192767..1193270 - 504 WP_000667001.1 hypothetical protein -
HVX91_RS05725 1193267..1194067 - 801 WP_000439795.1 hypothetical protein -
HVX91_RS05730 1194091..1194570 - 480 WP_000186629.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
HVX91_RS05735 1194774..1195568 - 795 WP_046081753.1 TraB/GumN family protein -
HVX91_RS05740 1195701..1196003 + 303 WP_000057541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX91_RS05745 1196039..1196380 + 342 WP_000806442.1 HigA family addiction module antidote protein Antitoxin
HVX91_RS05750 1196438..1198942 - 2505 WP_181812320.1 copper-exporting P-type ATPase CopA -
HVX91_RS05755 1199249..1200538 + 1290 WP_000102764.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11795.37 Da        Isoelectric Point: 10.2638

>T165520 WP_000057541.1 NZ_CP057565:1195701-1196003 [Escherichia fergusonii]
MAQKNNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

>T165520 NZ_CP073914:3891262-3891690 [Proteus terrae subsp. cibarius]
GTGGTAAAATTTACCATAGTAAAAACTACCACAGGGGAAGTGATGGTTATCTATAAAACAAAGATGTTCAAAAACAGTTT
CAAGAAAATGCCTATCAATGATGCTGCTTTAATAGATATTGCCAACGAAGTATATGCAGGACACTTTGAAGCTGACTTAG
GTGGGGGGATTATCAAAAAACGGATCTGTATCCATGGAAAAGGAAAGAGTAGTGGAATTAGAACAATTATATTTTATAAA
CAGGGAAGTAATTTATTCTTTGCTGATGGATGGAAAAAATCTCACTTGAGCGCTAAAAAATCTAAAGAAATTACAGATGA
TGAACTAGAATCCTATAAAGATCTGGCAAAAGATCTCTTCAGTGCAACTAAAAATAAAATAGATAAGATGGTTGCACTAG
GCCTTTTAACGGAGGTTAAACATGACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT165520 WP_000806442.1 NZ_CP057565:1196039-1196380 [Escherichia fergusonii]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp

>AT165520 NZ_CP073914:3891683-3892003 [Proteus terrae subsp. cibarius]
ATGACTGATAAAATGCAAGAAATGCTGAAATTTGCACAAGAAATGGAAGTTGCGGGAATAACCGATGGAGAATCGGCTAG
ACGAATTGCAGCGAGAATAAAAGCCAAAGAATTAAAAGAAAGATATGCTCACCTGACTCCAATGAATGGTGAAGATATAA
AAAGAATTCGCGAGCAAAATAATATTTCGCAATCGTCTCTTGCTTTAATACTAAATATGACAAAAGAGAGCGTATCAAAA
TGGGAGCGGAACGAAATTAAACCCAATGGAGCTGCATTGAGACTTTTGAATTTAATAGATAATAAAGCAATTTCAATCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A1R1

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References