Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 982403..982649 Replicon chromosome
Accession NZ_CP057565
Organism Escherichia fergusonii strain RHB23-C01

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag HVX91_RS04665 Protein ID WP_000956458.1
Coordinates 982497..982649 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 982403..982455 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX91_RS04650 977911..979710 + 1800 WP_000211943.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
HVX91_RS04655 979710..981422 + 1713 WP_046083135.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
HVX91_RS04660 981496..982230 + 735 WP_046083134.1 phosphoadenosine phosphosulfate reductase -
- 982403..982455 - 53 - - Antitoxin
HVX91_RS04665 982497..982649 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
HVX91_RS04670 982885..985542 + 2658 WP_181812268.1 CRISPR-associated helicase Cas3' -
HVX91_RS04675 985640..987202 + 1563 WP_181812269.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T165518 WP_000956458.1 NZ_CP057565:982497-982649 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T165518 NZ_CP073914:3478592-3478915 [Proteus terrae subsp. cibarius]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGATCAGATCCTCGATATGCCACCCAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAATCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAAATGAGCTCAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin


Download         Length: 53 bp

>AT165518 NZ_CP057565:c982455-982403 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References