Detailed information of TA system TA165516

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 679469..679727
• Replicon: chromosome
• Accession: NZ_CP057565
• Organism: Escherichia fergusonii strain RHB23-C01

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVX91_RS03280
• Protein ID: WP_000935262.1
• Coordinates: 679469..679678 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	679670..679727 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX91_RS03260	674534..675121	+	588	WP_046083027.1	molybdopterin adenylyltransferase	-
HVX91_RS03265	675155..675721	-	567	WP_000528529.1	acetate uptake transporter	-
HVX91_RS03270	676229..678145	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVX91_RS03275	678234..679364	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVX91_RS03280	679469..679678	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	679670..679727	+	58	-	-	Antitoxin
HVX91_RS03285	680162..681328	+	1167	WP_181812211.1	Na+/H+ antiporter NhaA	-
HVX91_RS03290	681396..682295	+	900	WP_000019049.1	transcriptional activator NhaR	-
HVX91_RS03295	682391..682654	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVX91_RS03300	682757..682975	+	219	WP_012599853.1	DUF2575 family protein	-
HVX91_RS03305	682983..683924	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165516 WP_000935262.1 NZ_CP057565:c679678-679469 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165516 NZ_CP073910:c4746467-4746171 [Sphingobium phenoxybenzoativorans]
ATGGACATGCGGTTCGAATGGGACCCGGACAAGGCGGCCAGCAATCGCGCCAAGCATGGCGTCAGTTTCGATTTAGCCAT
GCGCGCCTTTGCCGATCCTTTTGCGCTAAGCGTTCAGGACAGGATCGAAGGCGGCGAGTTTCGCTGGCAATTGCTGGGCA
TGGTCGAGGGGCGAGTGCTGTTGCTGGTTGCGCATACGGTGCGGGATGAACGCGACGGCGGCGAGACCATCCGCATTATT
TCCGCCCGGCGGGCTACGGCCGGGGAGAGGAGGCGCTATGAACAACAGGCTTTCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165516 NZ_CP057565:679670-679727 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin