Detailed information of TA system TA165507

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4300222..4300480
• Replicon: chromosome
• Accession: NZ_CP057561
• Organism: Escherichia fergusonii strain RHB23-C02

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: HVX92_RS20565
• Protein ID: WP_181202950.1
• Coordinates: 4300222..4300374 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4300425..4300480 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX92_RS20540	4296087..4296797	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVX92_RS20545	4297235..4298605	+	1371	WP_181812031.1	MFS transporter	-
HVX92_RS20550	4298855..4299145	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVX92_RS20555	4299427..4299639	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVX92_RS20560	4299693..4300064	-	372	WP_072274202.1	membrane protein insertion efficiency factor YidD	-
HVX92_RS20565	4300222..4300374	-	153	WP_181202950.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4300425..4300480	+	56	-	-	Antitoxin
HVX92_RS20570	4300675..4301034	-	360	WP_141095883.1	hypothetical protein	-
HVX92_RS20575	4301103..4303172	-	2070	WP_181812032.1	glycine--tRNA ligase subunit beta	-
HVX92_RS20580	4303182..4304093	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVX92_RS20585	4304189..4304488	-	300	WP_024256552.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5926.17 Da
• Isoelectric Point: 6.9160

>T165507 WP_181202950.1 NZ_CP057561:c4300374-4300222 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165507 NZ_CP073907:c137009-136527 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT165507 NZ_CP057561:4300425-4300480 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin