Detailed information of TA system TA165501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokA/Ldr(toxin)
• Location: 4269427..4269646
• Replicon: chromosome
• Accession: NZ_CP057561
• Organism: Escherichia fergusonii strain RHB23-C02

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A826RQE3
• Locus tag: HVX92_RS20410
• Protein ID: WP_000170746.1
• Coordinates: 4269427..4269534 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4269592..4269646 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX92_RS20385	4264663..4265430	-	768	WP_181812029.1	cellulose biosynthesis protein BcsQ	-
HVX92_RS20390	4265442..4265630	-	189	WP_001063310.1	YhjR family protein	-
HVX92_RS20395	4265917..4267476	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
HVX92_RS20400	4267473..4267664	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVX92_RS20405	4267661..4269340	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVX92_RS20410	4269427..4269534	-	108	WP_000170746.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4269592..4269646	+	55	NuclAT_16	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_16	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_16	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_16	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_18	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_18	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_18	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_18	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_20	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_20	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_20	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_20	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_22	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_22	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_22	-	Antitoxin
-	4269592..4269646	+	55	NuclAT_22	-	Antitoxin
-	4269592..4269648	+	57	NuclAT_12	-	-
-	4269592..4269648	+	57	NuclAT_12	-	-
-	4269592..4269648	+	57	NuclAT_12	-	-
-	4269592..4269648	+	57	NuclAT_12	-	-
-	4269592..4269648	+	57	NuclAT_14	-	-
-	4269592..4269648	+	57	NuclAT_14	-	-
-	4269592..4269648	+	57	NuclAT_14	-	-
-	4269592..4269648	+	57	NuclAT_14	-	-
HVX92_RS20415	4269909..4270016	-	108	WP_072132476.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVX92_RS20420	4270391..4270498	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVX92_RS20425	4270874..4270981	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4271030..4271093	+	64	NuclAT_15	-	-
-	4271030..4271093	+	64	NuclAT_15	-	-
-	4271030..4271093	+	64	NuclAT_15	-	-
-	4271030..4271093	+	64	NuclAT_15	-	-
-	4271030..4271093	+	64	NuclAT_17	-	-
-	4271030..4271093	+	64	NuclAT_17	-	-
-	4271030..4271093	+	64	NuclAT_17	-	-
-	4271030..4271093	+	64	NuclAT_17	-	-
-	4271030..4271093	+	64	NuclAT_19	-	-
-	4271030..4271093	+	64	NuclAT_19	-	-
-	4271030..4271093	+	64	NuclAT_19	-	-
-	4271030..4271093	+	64	NuclAT_19	-	-
-	4271030..4271093	+	64	NuclAT_21	-	-
-	4271030..4271093	+	64	NuclAT_21	-	-
-	4271030..4271093	+	64	NuclAT_21	-	-
-	4271030..4271093	+	64	NuclAT_21	-	-
-	4271030..4271095	+	66	NuclAT_11	-	-
-	4271030..4271095	+	66	NuclAT_11	-	-
-	4271030..4271095	+	66	NuclAT_11	-	-
-	4271030..4271095	+	66	NuclAT_11	-	-
-	4271030..4271095	+	66	NuclAT_13	-	-
-	4271030..4271095	+	66	NuclAT_13	-	-
-	4271030..4271095	+	66	NuclAT_13	-	-
-	4271030..4271095	+	66	NuclAT_13	-	-
HVX92_RS20430	4271417..4272613	+	1197	WP_001016304.1	methionine gamma-lyase	-
HVX92_RS20435	4272863..4274161	+	1299	WP_001152712.1	amino acid permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3912.73 Da
• Isoelectric Point: 9.0157

>T165501 WP_000170746.1 NZ_CP057561:c4269534-4269427 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVITGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165501 NZ_CP073906:c4678123-4677590 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT165501 NZ_CP057561:4269592-4269646 [Escherichia fergusonii]
CAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A826RQE3

Antitoxin