Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2354455..2355017 Replicon chromosome
Accession NZ_CP057506
Organism Citrobacter freundii strain RHB24-C05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVY06_RS11370 Protein ID WP_096757033.1
Coordinates 2354455..2354733 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVY06_RS11375 Protein ID WP_096757032.1
Coordinates 2354733..2355017 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY06_RS11350 2349564..2349995 - 432 WP_096757037.1 OsmC family protein -
HVY06_RS11355 2350224..2350364 + 141 WP_096757036.1 stationary-phase-induced ribosome-associated protein -
HVY06_RS11360 2350544..2352241 + 1698 WP_115258488.1 malate dehydrogenase -
HVY06_RS11365 2352552..2354267 + 1716 WP_181819369.1 ATP-binding cassette domain-containing protein -
HVY06_RS11370 2354455..2354733 + 279 WP_096757033.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY06_RS11375 2354733..2355017 + 285 WP_096757032.1 HigA family addiction module antidote protein Antitoxin
HVY06_RS11380 2355122..2355778 - 657 WP_096757031.1 formate dehydrogenase-N subunit gamma -
HVY06_RS11385 2355771..2356655 - 885 WP_115258486.1 formate dehydrogenase N subunit beta -
HVY06_RS11390 2356669..2359716 - 3048 WP_137398860.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10601.05 Da        Isoelectric Point: 9.5320

>T165454 WP_096757033.1 NZ_CP057506:2354455-2354733 [Citrobacter freundii]
MIMNFRHKGLRDLFLQGRTSGVTAKHVRRLRHRLAVIDAASHVTDINMPGYKLHALTGDRDGVWSISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T165454 NZ_CP073883:395274-395483 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10327.05 Da        Isoelectric Point: 8.8094

>AT165454 WP_096757032.1 NZ_CP057506:2354733-2355017 [Citrobacter freundii]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAQ
KSVDISRLRKLVAQ

Download         Length: 285 bp

>AT165454 NZ_CP073883:394974-395267 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References