Detailed information of TA system TA165447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4217913..4218170
• Replicon: chromosome
• Accession: NZ_CP057505
• Organism: Escherichia fergusonii strain RHB24-C06

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: S1E8G5
• Locus tag: HVY07_RS20120
• Protein ID: WP_001135732.1
• Coordinates: 4217913..4218065 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4218122..4218170 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY07_RS20095	4213107..4214081	+	975	WP_000804666.1	glyoxylate/hydroxypyruvate reductase GhrB	-
HVY07_RS20100	4214174..4214884	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
HVY07_RS20105	4215322..4216692	+	1371	WP_181673780.1	MFS transporter	-
HVY07_RS20110	4216942..4217232	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
HVY07_RS20115	4217512..4217724	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HVY07_RS20120	4217913..4218065	-	153	WP_001135732.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4218122..4218170	+	49	-	-	Antitoxin
HVY07_RS20125	4218387..4220456	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
HVY07_RS20130	4220466..4221377	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
HVY07_RS20135	4221472..4221771	-	300	WP_024256552.1	YsaB family lipoprotein	-
HVY07_RS20140	4221943..4222938	+	996	WP_181673781.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5998.28 Da
• Isoelectric Point: 7.7169

>T165447 WP_001135732.1 NZ_CP057505:c4218065-4217913 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T165447 NZ_CP073878:1024898-1025077 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT165447 NZ_CP057505:4218122-4218170 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: S1E8G5

Antitoxin