Detailed information of TA system TA165445

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokC/Ldr(toxin)
• Location: 4189108..4189327
• Replicon: chromosome
• Accession: NZ_CP057505
• Organism: Escherichia fergusonii strain RHB24-C06

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: -
• Locus tag: HVY07_RS19990
• Protein ID: WP_181673774.1
• Coordinates: 4189108..4189215 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4189264..4189327 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY07_RS19965	4184640..4184828	-	189	WP_001063310.1	YhjR family protein	-
HVY07_RS19970	4185115..4186674	+	1560	WP_181673773.1	cellulose biosynthesis protein BcsE	-
HVY07_RS19975	4186671..4186862	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVY07_RS19980	4186859..4188538	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVY07_RS19985	4188625..4188732	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4188790..4188844	+	55	NuclAT_13	-	-
-	4188790..4188844	+	55	NuclAT_13	-	-
-	4188790..4188844	+	55	NuclAT_13	-	-
-	4188790..4188844	+	55	NuclAT_13	-	-
-	4188790..4188844	+	55	NuclAT_15	-	-
-	4188790..4188844	+	55	NuclAT_15	-	-
-	4188790..4188844	+	55	NuclAT_15	-	-
-	4188790..4188844	+	55	NuclAT_15	-	-
-	4188790..4188844	+	55	NuclAT_17	-	-
-	4188790..4188844	+	55	NuclAT_17	-	-
-	4188790..4188844	+	55	NuclAT_17	-	-
-	4188790..4188844	+	55	NuclAT_17	-	-
-	4188790..4188844	+	55	NuclAT_19	-	-
-	4188790..4188844	+	55	NuclAT_19	-	-
-	4188790..4188844	+	55	NuclAT_19	-	-
-	4188790..4188844	+	55	NuclAT_19	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
HVY07_RS19990	4189108..4189215	-	108	WP_181673774.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4189264..4189327	+	64	NuclAT_12	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_12	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_12	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_12	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_14	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_14	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_14	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_14	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_16	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_16	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_16	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_16	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_18	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_18	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_18	-	Antitoxin
-	4189264..4189327	+	64	NuclAT_18	-	Antitoxin
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
HVY07_RS19995	4189652..4190848	+	1197	WP_001016304.1	methionine gamma-lyase	-
HVY07_RS20000	4191098..4192396	+	1299	WP_046081028.1	amino acid permease	-
HVY07_RS20005	4192412..4193623	-	1212	WP_000256500.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3881.65 Da
• Isoelectric Point: 7.0034

>T165445 WP_181673774.1 NZ_CP057505:c4189215-4189108 [Escherichia fergusonii]
MTLAELGMDFWHDLAAPVIAGILASLIVSWLNKRK

Nucleotide

• Length: 108 bp

>T165445 NZ_CP073878:693198-693560 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165445 NZ_CP057505:4189264-4189327 [Escherichia fergusonii]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Antitoxin