Detailed information of TA system TA165441

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4188625..4188844
• Replicon: chromosome
• Accession: NZ_CP057505
• Organism: Escherichia fergusonii strain RHB24-C06

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVY07_RS19985
• Protein ID: WP_001295224.1
• Coordinates: 4188625..4188732 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4188790..4188844 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY07_RS19960	4183861..4184628	-	768	WP_000279500.1	cellulose biosynthesis protein BcsQ	-
HVY07_RS19965	4184640..4184828	-	189	WP_001063310.1	YhjR family protein	-
HVY07_RS19970	4185115..4186674	+	1560	WP_181673773.1	cellulose biosynthesis protein BcsE	-
HVY07_RS19975	4186671..4186862	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVY07_RS19980	4186859..4188538	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVY07_RS19985	4188625..4188732	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4188790..4188844	+	55	NuclAT_13	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_13	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_13	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_13	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_15	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_15	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_15	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_15	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_17	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_17	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_17	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_17	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_19	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_19	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_19	-	Antitoxin
-	4188790..4188844	+	55	NuclAT_19	-	Antitoxin
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_10	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
-	4188790..4188846	+	57	NuclAT_8	-	-
HVY07_RS19990	4189108..4189215	-	108	WP_181673774.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	4189264..4189327	+	64	NuclAT_12	-	-
-	4189264..4189327	+	64	NuclAT_12	-	-
-	4189264..4189327	+	64	NuclAT_12	-	-
-	4189264..4189327	+	64	NuclAT_12	-	-
-	4189264..4189327	+	64	NuclAT_14	-	-
-	4189264..4189327	+	64	NuclAT_14	-	-
-	4189264..4189327	+	64	NuclAT_14	-	-
-	4189264..4189327	+	64	NuclAT_14	-	-
-	4189264..4189327	+	64	NuclAT_16	-	-
-	4189264..4189327	+	64	NuclAT_16	-	-
-	4189264..4189327	+	64	NuclAT_16	-	-
-	4189264..4189327	+	64	NuclAT_16	-	-
-	4189264..4189327	+	64	NuclAT_18	-	-
-	4189264..4189327	+	64	NuclAT_18	-	-
-	4189264..4189327	+	64	NuclAT_18	-	-
-	4189264..4189327	+	64	NuclAT_18	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_7	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
-	4189264..4189329	+	66	NuclAT_9	-	-
HVY07_RS19995	4189652..4190848	+	1197	WP_001016304.1	methionine gamma-lyase	-
HVY07_RS20000	4191098..4192396	+	1299	WP_046081028.1	amino acid permease	-
HVY07_RS20005	4192412..4193623	-	1212	WP_000256500.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T165441 WP_001295224.1 NZ_CP057505:c4188732-4188625 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165441 NZ_CP073876:c2031151-2030942 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT165441 NZ_CP057505:4188790-4188844 [Escherichia fergusonii]
CAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin