Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3389273..3389967 Replicon chromosome
Accession NZ_CP057505
Organism Escherichia fergusonii strain RHB24-C06

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag HVY07_RS16155 Protein ID WP_181199277.1
Coordinates 3389273..3389671 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID A0A895NS01
Locus tag HVY07_RS16160 Protein ID WP_072668000.1
Coordinates 3389674..3389967 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY07_RS16130 3384637..3385095 - 459 WP_001291991.1 xanthine phosphoribosyltransferase -
HVY07_RS16135 3385356..3386813 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
HVY07_RS16140 3386870..3387484 - 615 WP_181673545.1 peptide chain release factor H -
HVY07_RS16145 3387481..3388620 - 1140 WP_181673546.1 RNA ligase RtcB family protein -
HVY07_RS16150 3388811..3389263 - 453 WP_181673547.1 GNAT family N-acetyltransferase -
HVY07_RS16155 3389273..3389671 - 399 WP_181199277.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
HVY07_RS16160 3389674..3389967 - 294 WP_072668000.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
HVY07_RS16165 3390020..3391075 - 1056 WP_181673548.1 DNA polymerase IV -
HVY07_RS16170 3391146..3392069 - 924 WP_181673549.1 putative lateral flagellar export/assembly protein LafU -
HVY07_RS16175 3392072..3392935 - 864 WP_001169517.1 flagellar motor stator protein MotA -
HVY07_RS16180 3392948..3393664 - 717 WP_181673550.1 FliA/WhiG family RNA polymerase sigma factor -
HVY07_RS16185 3393684..3394151 - 468 WP_000725253.1 flagellar basal body-associated FliL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3323775..3391075 67300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15530.91 Da        Isoelectric Point: 8.0934

>T165439 WP_181199277.1 NZ_CP057505:c3389671-3389273 [Escherichia fergusonii]
MRVFKTKLIRLQLTDKELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T165439 NZ_CP073876:c1890841-1890446 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11215.73 Da        Isoelectric Point: 5.2170

>AT165439 WP_072668000.1 NZ_CP057505:c3389967-3389674 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALIDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT165439 NZ_CP073876:c1891071-1890841 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References