Detailed information of TA system TA165428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 679582..679840
• Replicon: chromosome
• Accession: NZ_CP057505
• Organism: Escherichia fergusonii strain RHB24-C06

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HVY07_RS03290
• Protein ID: WP_000935262.1
• Coordinates: 679582..679791 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	679783..679840 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY07_RS03270	674647..675234	+	588	WP_181674018.1	molybdopterin adenylyltransferase	-
HVY07_RS03275	675268..675834	-	567	WP_000528529.1	acetate uptake transporter	-
HVY07_RS03280	676342..678258	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HVY07_RS03285	678347..679477	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HVY07_RS03290	679582..679791	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	679783..679840	+	58	-	-	Antitoxin
HVY07_RS03295	680275..681441	+	1167	WP_181674019.1	Na+/H+ antiporter NhaA	-
HVY07_RS03300	681509..682408	+	900	WP_000019050.1	transcriptional activator NhaR	-
HVY07_RS03305	682504..682767	-	264	WP_001274021.1	30S ribosomal protein S20	-
HVY07_RS03310	682870..683088	+	219	WP_012599853.1	DUF2575 family protein	-
HVY07_RS03315	683096..684037	+	942	WP_046081994.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T165428 WP_000935262.1 NZ_CP057505:c679791-679582 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T165428 NZ_CP073869:c1690869-1690690 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT165428 NZ_CP057505:679783-679840 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin