Detailed information of TA system TA165386

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4286476..4286695
• Replicon: chromosome
• Accession: NZ_CP057481
• Organism: Escherichia fergusonii strain RHB25-C10

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: HVY20_RS20535
• Protein ID: WP_001295224.1
• Coordinates: 4286476..4286583 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4286632..4286695 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY20_RS20510	4282005..4282193	-	189	WP_001063310.1	YhjR family protein	-
HVY20_RS20515	4282480..4284039	+	1560	WP_181665796.1	cellulose biosynthesis protein BcsE	-
HVY20_RS20520	4284036..4284227	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
HVY20_RS20525	4284224..4285903	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
HVY20_RS20530	4285990..4286097	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
HVY20_RS20535	4286476..4286583	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4286632..4286695	+	64	NuclAT_16	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_16	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_16	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_16	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_17	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_17	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_17	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_17	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_18	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_18	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_18	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_18	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_19	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_19	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_19	-	Antitoxin
-	4286632..4286695	+	64	NuclAT_19	-	Antitoxin
-	4286632..4286697	+	66	NuclAT_14	-	-
-	4286632..4286697	+	66	NuclAT_14	-	-
-	4286632..4286697	+	66	NuclAT_14	-	-
-	4286632..4286697	+	66	NuclAT_14	-	-
-	4286632..4286697	+	66	NuclAT_15	-	-
-	4286632..4286697	+	66	NuclAT_15	-	-
-	4286632..4286697	+	66	NuclAT_15	-	-
-	4286632..4286697	+	66	NuclAT_15	-	-
HVY20_RS20540	4287019..4288215	+	1197	WP_001016303.1	methionine gamma-lyase	-
HVY20_RS20545	4288464..4289762	+	1299	WP_001152711.1	amino acid permease	-
HVY20_RS20550	4289778..4290989	-	1212	WP_000256500.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T165386 WP_001295224.1 NZ_CP057481:c4286583-4286476 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T165386 NZ_CP073847:c2039582-2039373 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT165386 NZ_CP057481:4286632-4286695 [Escherichia fergusonii]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin